β受体阻滞剂对心衰患者心律失常的影响  

Randomized clinical trial of comparison of the effect of bisoprolol and carvedilol on arrhythmia in patients with chronic left heart failure

作　　者：黄岩[1] 王树贤[2] 成小如[1] 李一石[1] 

机构地区：[1]北京协和医学院,中国医学科学院,阜外心血管病医院,卫生部心血管药物临床研究重点实验室,临床药理中心,100037 [2]中国人民解放军305医院,100017

出　　处：《临床心电学杂志》2010年第1期27-28,共2页Journal of Clinical Electrocardiology

摘　　要：目的探讨比索洛尔与卡维地洛对心衰患者心律失常的作用。方法对40例慢性心衰患者随机分组进行比索洛尔和卡维地洛治疗,渐增至最大耐受剂量后观察16周,治疗前后行24h动态心电图检查进行对比,分析心律失常的变化情况。结果治疗后两组的心律失常均有一定改善,卡维地洛组更明显,对室性期前收缩的治疗效果显著,比索洛尔对房性期前收缩的治疗未显效。但治疗效果及两组间差异均无统计学意义。结论卡维地洛对心力衰竭患者心律失常的治疗效果较比索洛尔略高。Objective To study the effect of bisoprolol and carvedilol on arrhythmia in patients with chronicleft heart failure. Methods Forty patients with chronic left heart failure [ejection fraction （EF）less or equal to 40% by echocardiography were randomly assigned to either bisoprolol or carvedilol group who received conventional therapy. β-blockers were increased gradually to the target or the tolerant dosages and administrated for 4 months. Before and after therapy patients were examined with 24-hour dynamic electrocardiography and their arrhythmia were analysed. Results Improvements in arrhythmia were found in both groups. Carvedilol was more effective especially to premature ventricular contraction. Bisoprolol did not present effectiveness on premature atrial contraction. The effect of both drugs and the difference between two group were not significant in statistics. Conclusions The effect of carvedilol on arrhythmia in patients with chronic heart failure is better than bisoprolol slightly.

关 键 词：比索洛尔 卡维地洛 心律失常 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病] R541.7[医药卫生—内科学]