哺乳动物BMP4基因A型启动子的比较分析  

Comparative Analysis of the Mammalian BMP4 A-types Promoter

作　　者：张驰[1] 陈其新[1] 李明[1] 周建设[1] 秦楠[1] 

机构地区：[1]河南农业大学牧医工程学院,河南郑州450002

出　　处：《安徽农业科学》2010年第11期5560-5562,共3页Journal of Anhui Agricultural Sciences

基　　金：河南省重点科技攻关项目0524030011

摘　　要：以鸭嘴兽BMP4基因组序列为模型,采用比较基因组学方法分析哺乳动物BMP4基因A型启动子的结构特点。该研究分离出一段长112bp的进化上高度保守的核心启动子序列以及多个转录因子结合位点和CpG岛结构,并且在BMP4核心启动子区域发现了2种具有重要生物学功能的回文结构,为进一步研究该型启动子的转录调控功能提供了理论基础。同时以鸭嘴兽基因组为参照模型,也为今后研究其他哺乳动物进化上保留下来的基因提供更多新信息。The structural characteristias of BMP4 gene type-A promoter was analyzed by comparative genomics method.A 112 bp core promoter sequence.Highly conserved and many important transcription factors and CpG islands located in the promoter region were separated.Moreover,two important palindromes elements were found in Duckmole and human respectively.This study provided a foundation for studying the transcri-ptional regulatory function of this important promoter in mammal′s development.On the other hand,by using a Duckmole as model,it provided more new information for us to study the other mammals′evolution genes.

关 键 词：BMP4 启动子 CPG岛 回文结构 

分 类 号：Q953[生物学—动物学]