多囊卵巢综合征患者卵母细胞及早期胚胎发育潜能分析  

Developmental potential of oocyte and early embryo with polycystic ovary syndrome

作　　者：唐静文[1] 曹云霞[1] 

机构地区：[1]安徽医学大学第一附属医院生殖中心,合肥230022

出　　处：《安徽医科大学学报》2010年第2期220-223,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:30571954)

摘　　要：目的了解多囊卵巢综合征(PCOS)患者与卵巢排卵功能正常者之间卵母细胞及早期胚胎发育潜能的差异。方法在行GnRH-α降调长方案降调的控制性促排卵患者中,调查PCOS患者,行IVF-ET治疗67个周期,ICSI-ET治疗42个周期。同期治疗的217例月经正常妇女作为对照。结果IVF组内,PCOS患者与对照组卵母细胞成熟率(90.6%vs89.9%)、受精率(80.3%vs79.1%)、卵裂率(92.7%vs91.3%)、种植率(18.4%vs17.3)、临床妊娠率(33.3%vs31.1%)、活产率(28.8%vs25.1%),差异无统计学意义(P>0.05)。PCOS患者D3优质胚胎率高于对照组(44.1%vs37.7%,P<0.05)。ICSI组内,PCOS患者与对照组卵母细胞成熟率(88.5%vs90.4%)、受精率(75.0%vs75.8%)、卵裂率(92.8%vs91.3%)、种植率(24.7%vs22.5%)、临床妊娠率(40.5%vs37.5%)、活产率(33.3%vs29.7%)、D3优质胚胎率(34.3%vs37.7%),差异均无统计学意义(P>0.05)。结论相对于月经正常的妇女,PCOS患者在促排卵治疗中可获得较多的卵母细胞与优质胚胎。然而两者间卵母细胞成熟率及早期胚胎发育潜能差异无统计学意义,妊娠结局无明显不同。Objective To compare the developmental potential of oocyte and early embryo between women with polycystic ovarian syndrome and normo-ovulatory undergoing in vitro fertilisation（IVF）and intracytoplasmic sperm injection （ICSI） respectively.Methods During control ovarian hyperstimulation with long GnRH analogue down-regulation,we investigated PCOS patients consisted of 42 in ICSI cycle（group PCOS ICSI ）and 67 in IVF-ET cycle（group PCOS IVF）.217 normo-ovulatory women patients randomly selected as control.Results In IVF group,there was no significant statistically difference in term of oocyte mature rate（90.6% vs 89.9%）,fertilization rate （80.3% vs 79.1%）,cleavage rate（92.7% vs 91.3%）,implantation rate （18.4% vs 17.3）,clinical pregnancy rate per transfer （33.3% vs 31.1%）and Live birth rate （28.8% vs 25.1%） between pcos patients and the control.While the good quality embryo rate on day 3 （44.1% vs 37.7%） was significantly higher in PCOS group.In ICSI group,there was no significant statistically difference in term of oocyte mature rate（88.5% vs 90.4%）,fertilization rate （75.0% vs 75.8%）,cleavage rate（92.8% vs 91.3%）,implantation rate （24.7% vs 22.5%）,clinical pregnancy rate per transfer （40.5% vs 37.5%）,live birth rate （33.3% vs 29.7%） and good quality embryo rate on day 3（34.3% vs 37.7%） between pcos patients and the control.Conclusion Compare to normo-ovulatory women,PCOS patients can get more oocytes and more good embryos in one controlled ovarian hyperstimulation cycle.However,developmental potential of oocyte and early embryo are similar with no significant differences in pregnancy outcome.

关 键 词：多囊卵巢综合征 卵母细胞/生长和发育 胚胎发育 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学] R321.3[医药卫生—基础医学]