异种器官移植的新进展  

Current Advance of Xenotransplantation

作　　者：杜冰清[1] 麦刚[1] 陈拥华[1] 向光明[1] 龚军[1] 郑振江[1] 

机构地区：[1]四川大学华西医院肝胆胰外科,成都610041

出　　处：《中国普外基础与临床杂志》2010年第4期338-342,共5页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的总结异种器官移植的新进展。方法分析近年来异种器官移植进展的文献报道。结果随着免疫生物学的深入研究,异种器官移植取得了长足的进步,并开始应用于临床,但免疫排斥反应的诸多问题仍在探寻之中。结论异种移植为解决器官衰竭患者移植器官短缺的问题展现了广阔的前景,如何更有效地抑制排斥反应及延长移植物生存期是今后研究的重点。Objective To summarize the current advance of xenotransplantation.Methods Relevant literatures about current advance of xenotransplantation published recently domestic and abroad were collected and reviewed.Results Major progress of xenotransplantation had been made in the understanding of xenoimmunobiology in the last two decades and in the threshold of clinical application.However,many problems of immunological rejection were still needed to be explored and resolved.Conclusion Xenotransplantation as a transplantation source has an extensive potential to resolve the shortage of transplanted organs for end-stage organ failure,how to suppress rejection and prolong survival of grafts more effectively is a focal point of search in the future.

关 键 词：异种移植 超急性排斥反应 急性排斥反应 慢性排斥反应 转基因猪 异种耐受 

分 类 号：R617[医药卫生—外科学] R392.4[医药卫生—临床医学]