2型糖尿病患者颈动脉粥样硬化与动态血糖波动的关系  

The correlation between carotid atherosclerosis and blood glucose fluctuation in patients with type 2 diabetes mellitus

作　　者：彭朝胜[1] 曹悦鞍[1] 田力[1] 张文洛[1] 刘淑云[1] 

机构地区：[1]海军总医院干三科,北京100037

出　　处：《中国糖尿病杂志》2010年第4期273-275,共3页Chinese Journal of Diabetes

摘　　要：目的探讨T2DM伴颈动脉硬化(CAC)患者动态血糖波动的特点。方法 88例受试者分T2DM伴颈动脉硬化(CAC)组38例,T2DM无颈动脉硬化(NCAC)组35例和正常对照(NC)组15例,采用动态血糖监测系统(CGMS)监测三组72h血糖变化,计算日内平均血糖波动幅度(MAGE)和血糖波动系数(BGFC)。计算胰岛素抵抗指数HOMA-IR,对相关数据进行对比分析。结果 CAC组BGFC、MAGE及HOMA-IR明显高于NCAC组(P均<0.05);CAC组颈动脉内中膜厚度(IMT)与BGFC、MAGE及HOMA-IR呈正相关(r分别为0.352、0.360、0.336,P均<0.05);CAC组BGFC、MAGE与HOMA-IR呈正相关(r分别为0.341、0.362,P均<0.05)。结论 2型糖尿病颈动脉硬化与血糖波动相关,血糖波动可能促进了颈动脉硬化的发生与发展。Objective To investigate the relation between carotid atherosclerosis（CAC） and blood glucose fluctuation in patients with type 2 diabetes mellitus （T2DM）. Methods 73 diabetics and 15 normal subjects were divided into three groups ： T2DM with CAC （n = 38）, T2DM without CAC （n = 35 ） and normal control（n= 15）. The fluctuating feature of 72 hours blood glucose were recorded by continuous glucose monitoring systems（CGMS） and the insulin resistance index （InRI） was compared. Results In diabetic patients with CAC versus with NCAC, the blood glucose fluctuant coefficient （BGFC）, mean amplitude glycemic excursions （MAGE） and InRI were significantly higher （P〈 0. 05）. In CAC group, BGFC,MAGE and InRI were positively correlated with IMT, and BGFC and MAGE were positively correlated with the InRI （all P^0.05）. Conclusions There is a correlation between the blood glucose fluctuation and CAC in patients with T2DM.

关 键 词：糖尿病 2型 颈动脉硬化 动态血糖监测 血糖波动 

分 类 号：R587.1[医药卫生—内分泌] R543.4[医药卫生—内科学]