糖代谢异常对肱动脉内皮舒张功能影响的研究  

Study on the effect of abnormal glucose metabolism on the endothelial function in brachial artery

作　　者：赵君智 顿国亮 谭深[1] 李涛[1] 张景峰[1] 姬永浩 麦兴盛 

机构地区：[1]陕西省宝鸡市中心医院功能科,721008

出　　处：《中国糖尿病杂志》2010年第4期279-280,共2页Chinese Journal of Diabetes

摘　　要：目的探讨葡萄糖代谢异常对肱动脉血管内皮舒张功能的影响。方法应用高分辨率超声测量39例糖耐量减低(IGT)、47例T2DM和44例糖耐量正常者(NGT)反应性充血前后及含服硝酸甘油后肱动脉内径的变化。结果 IGT、T2DM组肱动脉内皮舒张功能均受损,T2DM组、NGT组分别与IGT组比较,差异有统计学意义(P<0.05),T2DM组较NGT组差异明显(P<0.01)。与NGT组比,IGT组、T2DM组FPG、HbA_1c、LDL-C升高,与内皮依赖性血管舒张功能(EDVR)负相关;HDL-C降低,与EIDVR正相关(P均<0.01)。结论葡萄糖代谢异常可对肱动脉内皮舒张功能造成损伤。Objective To study effects of abnormal glucose metabolism on the endothelial function in braehial artery. Methods We measured endotheliun-dependent and endothelium-independent brachial artery dilatation in patients with impaired glucose tolerance （IGT, n ： 39）, T2DM（n = 47） and NGT（n = 44） by using high resolution ultrasound. Results The endothelial dilatation functions （EDF） were damaged in IGT and T2DM groups,and were more damaged in T2DM than in NGT group（P^0. 01）. The FPG, HbAlc and LDL-C were elevated in IGT and T2DM as compared with NGT, and were negatively associated with EDF, HDL-C was positively correlated with EDF. Conclusions Abnormal glucose metabolism damages vascular endothelial dilatation function.

关 键 词：葡萄糖代谢异常 肱动脉 内皮功能 高分辨率超声 

分 类 号：R587.1[医药卫生—内分泌]