血红素氧合酶1基因-413A/T位点多态性与血脂异常个体冠心病患病风险密切相关  

-413A/T Polymorphism in Heme Oxygenase-1 Gene Promoter is Related to Susceptibility of Coronary Artery Disease in Patients with Dyslipidemia

作　　者：张国红[1] 陈宋明[2] 王东明[2] 黄贤生[2] 

机构地区：[1]汕头大学医学院病理教研室,广东省汕头市515031 [2]汕头大学医学院附属第一医院心血管内科,广东省汕头市515041

出　　处：《中国动脉硬化杂志》2010年第1期63-66,共4页Chinese Journal of Arteriosclerosis

基　　金：广东省自然科学基金(07008215)

摘　　要：目的检测血红素氧合酶1基因启动子区-413A/T位点多态性,阐明血红素氧合酶1基因多态性与冠心病易感性的关联。方法选择经冠状动脉造影确诊的冠心病患者200例为病例组,冠状动脉无明显狭窄、年龄、性别与病例组相仿的120例个体为对照。启动子区直接测序方法检测-413A/T单核苷酸多态性基因型。以冠心病危险因素作为协变量,统计血红素氧合酶1基因-413A/T位点多态性与冠心病的相关性。结果研究人群-413位点为单核苷酸多态性位点,且携带TT基因型的血脂异常患者冠心病患病风险明显减少(校正后OR=0.179,95%CI=0.05～0.642)。结论血红素氧合酶1基因启动子区-413A/T可能是评价血脂异常个体冠心病易感性风险的重要标记。Aim To investigate the relationship between-413A/T single nucleotide polymorphism in heme oxygenase-1（HO-1）gene promoter and susceptibility of coronary artery disease.Methods 200 patients who were diagnosed as having coronary artery disease by coronary angiography were selected in this study.120 subjects without evidence of coronary artery disease under coronary angiography with their sex and age similar to coronary artery disease patients were selected as controls.Sequencing was carried out on the ABI 3730 DNA analysis platforms to determine the genotypes of-413A/T.Results A single nucleotide polymorphism A（-413）T was found in the HO-1 gene promoter.Genotype T/T was protective against coronary artery disease in patients with dyslipimedia（adjusted OR=0.179,95%CI=0.05～0.642）.Conclusion A（-413）T single nucleotide polymorphism may be an important marker to evaluate susceptibility to coronary artery disease in patients with dyslipidemia.

关 键 词：冠心病 血红素氧合酶1 基因多态性 血脂异常 

分 类 号：R5[医药卫生—内科学]