2型糖尿病内脂素和脂联素水平与颈动脉内膜中膜厚度的相关性  

Association of Plasma Visfatin and Adiponectin with Intima-Media Thickness of Carotid Artery in Type 2 Diabetes Mellitus

作　　者：赵占胜[1] 高丽华[1] 田晖[2] 吴冰洁[3] 贾丽梅[3] 王绵[1] 邓永贵[1] 周红[1] 张力辉[1] 苏胜偶[1] 

机构地区：[1]河北医科大学第二医院内分泌科,河北省石家庄市050000 [2]河北医科大学第二医院功能科,河北省石家庄市050000 [3]河北医科大学第二医院体检中心,河北省石家庄市050000

出　　处：《中国动脉硬化杂志》2010年第1期67-70,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的研究2型糖尿病患者血浆内脂素和脂联素水平的变化,并探讨其与颈动脉内膜中膜厚度的关系。方法73例2型糖尿病患者根据颈动脉超声结果分为颈动脉内膜中膜厚度增厚组37例,颈动脉内膜中膜厚度正常组36例;分别测定其血浆内脂素和脂联素,分析两者与颈动脉内膜中膜厚度变化的关系。结果2型糖尿病患者内脂素水平高于对照组,且颈动脉内膜中膜厚度增厚组高于颈动脉内膜中膜厚度正常组(P<0.01)。2型糖尿病组的脂联素水平低于对照组,且颈动脉内膜中膜厚度增厚组低于颈动脉内膜中膜厚度正常组(P<0.01)。多元逐步回归分析显示,内脂素与颈动脉内膜中膜厚度、内脏脂肪厚度、空腹胰岛素呈正相关;脂联素与颈动脉内膜中膜厚度、胰岛素抵抗指数呈负相关,与高密度脂蛋白胆固醇呈正相关。颈动脉内膜中膜厚度与内脂素、年龄、糖化血红蛋白呈正相关,与脂联素呈负相关。结论血浆内脂素增高及脂联素水平的降低可能是2型糖尿病患者合并早期动脉粥样硬化的危险因素之一。Aim To investigate the changes of visfatin and adiponectin（APN）levels in patients with type 2 diabetes mellitus（T2DM）,and their relation with intima-media thickness（IMT）of the carotid artery.Methods According to the IMT level,the 73 diabetic patients were divided into two subgroups：IMT thickened group（37 cases）and IMT normal group（36 cases）.Plasma visfatin and APN levels were examined.The relationship between visfatin,APN and IMT were investigated.Results Plasma visfatin was elevated in T2DM patients as compared with that in normal control group（P〈0.01）,and more in IMT thickened group than in IMT normal group（P〈0.01）.Plasma APN was lower in the diabetic group as compared with that in controls（P〈0.01）.It was also lower in IMT thickened group compared with those in IMT normal group（P〈0.01）.Multiple stepwise regression analysis revealed that visfatin level was positively related to IMT,visceral fat thickness and fasting insulin.There was positive correlation between adiponectin level and HDLC,but it was negatively correlated with HOMA-IR and waist-hip ratio in these T2DM patients.Visfatin,age and HbAlC were positively correlated with IMT,and APN was negatively correlated with IMT.Conclusion Elevated plasma visfatin and descended APN may be one of probable risk factors in the early atherosclerosis in the patients with T2DM.

关 键 词：内脂素 脂联素 2型糖尿病 动脉内膜中层厚度 

分 类 号：R5[医药卫生—内科学]