犬单侧输尿管梗阻再通术后肾功能恢复的动态观察  

Dynamic observation of the restoration of renal function in dogs after re-canalization of unilateral ureteral obstruction

作　　者：高莉[1] 王淑贞[1] 汪彤[1] 杨付勇[1] 

机构地区：[1]山东大学齐鲁医院核医学科,济南250012

出　　处：《山东大学学报（医学版）》2010年第4期64-66,共3页Journal of Shandong University:Health Sciences

摘　　要：目的对不同时点输尿管梗阻再通术后肾功能恢复情况做动态观察。方法将24只犬随机分成3组,行左输尿管结扎制作输尿管梗阻模型。分别在梗阻后第1、4、8周行输尿管再通术,于梗阻术前、后及再通术后2周、4个月进行放射性核素(99mTc-DTPA)显像,观察梗阻肾功能恢复的影像变化,并计算肾小球滤过率。结果输尿管梗阻1周组犬行再通术后肾功能可完全恢复到正常水平;4周组犬行再通术后肾功能仅能有部分恢复;8周组犬行再通术后未观察到肾功能恢复。结论输尿管梗阻时间是影响犬肾功能恢复的关键因素,越早行输尿管再通术,肾脏的功能恢复越好。Objective To perform dynamic observation of the restoration of renal function at different time points after re-canalization of ureteral obstruction. Methods Twenty-four dogs were randomly divided into 3 groups to produce the ureteral obstruction model by ligation of the left ureter. The ureteral re-canalization was done 1,4,or 8 weeks after the ligation,and radionuclide（^99mTc-DTPA）scanning was carried out before or after obstruction and the two weeks or four months after re-canalization. Changes of images of the restoration of renal function were observed and glomerular filtration rate（GFR） was calculated. Results The renal function in dogs that received re-canalization 1 week after ureteral obstruction was fully restored to normal level; renal function in dogs of 4 weeks obstruction was only partially restored after re-canalization; no restoration of renal function was observed in dogs that received re-canalization 8 weeks after obstruction. Conclusions Duration of the ureteral obstruction is the key factor affecting the recovery of renal function in dogs. The better restoration of renal function depends on early ureteral re-canalization.

关 键 词：输尿管梗阻 肾功能 犬 

分 类 号：R817.4[医药卫生—影像医学与核医学]