诺和锐30特充强化治疗初诊2型糖尿病疗效观察  

Effects of Aspart 30 for new type 2 diabetes

作　　者：张月华[1] 赵新国[1] 岳玉国[1] 吕英俊[1] 

机构地区：[1]武警浙江省总队医院内分泌科,浙江嘉兴314000

出　　处：《山东大学学报（医学版）》2010年第4期160-161,164,共3页Journal of Shandong University:Health Sciences

摘　　要：目的观察初诊2型糖尿病患者经诺和锐30特充强化治疗后胰岛β细胞功能的变化。方法对55例初诊为2型糖尿病的患者进行为期2周的诺和锐30特充治疗,每日3次皮下注射,分析治疗前后口服葡萄糖耐量试验(OGTT)时空腹血糖(FPG)、糖负荷后血糖(PPG)、胰岛素、C-肽、胰岛素及C-肽曲线下面积、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-B)等指标的变化。结果短期诺和锐30特充强化治疗后,FPG、PPG较治疗前明显下降(P<0.01),胰岛素、C-肽、胰岛素及C-肽曲线下面积、HOMA-B较治疗前明显升高(P<0.01),HO-MA-IR较治疗前明显下降(P<0.05)。总胆固醇、甘油三脂治疗前后差异无统计学意义(P>0.05)。结论短期诺和锐30特充强化治疗可迅速降低血糖,改善胰岛β细胞功能,减轻胰岛素抵抗。Objective To observe changes in Pancreatic β-cells in newly diagnosed type 2 diabetic patients after intensive treatments with short term insulin Aspart 30. Method 55 patients,who were newly diagnosed as type 2 diabetics, were treated by 3 hypodermic injections with Aspart 30 per day. After two weeks intensive treatments,the levels of TC （total cholesterin）,triglyceride（TG）,fasting plasma glucose（ FPG）,2 hours postprandial glucose（2hPG）,insulin,Cpeptide,the mean area under the curve of insulin and C-peptide,insulin resistance index（HOMA-IR ）,and insulin secretion index （HOMA-B） were compared before and after the treatments. Results After short term intensive treatments,the levels of FPG and 2hPG were significantly decreased（P〈 0. 01）. The levels of insulin,C-peptide,and HOMA-B,and the mean area under the curves of insulin and C-peptide were significantly increased（P〈 0. 01） after the treatments. However,the level of HOMA-IR was significantly decreased （P〈 0. 05） after the treatments. But there were no remarkable changes in TC and TG before and after the treatments. Conclusion Short term intensive insulin treatment by Aspart 30 can effectively reduce the level of plasma glucose,improves the β-cell function and releases the insulin resistance.

关 键 词：糖尿病 非胰岛素依赖型 强化治疗 诺和锐30特充 胰岛Β细胞功能 

分 类 号：R587.2[医药卫生—内分泌]