Dielectric monitoring method for the drug release mechanism of drug-loading chitosan microspheres  

作　　者：FANG Ming GAO JinLong WANG Sheng LIAN YiWei ZHAO KongShuang 

机构地区：[1]College of Chemistry, Beijing Normal University, Beijing 100875, China

出　　处：《Chinese Science Bulletin》2010年第13期1246-1254,共9页

基　　金：supported by the National Natural Science Foundation of China (Grant No. 20976015 and 20673014)

摘　　要：The chitosan microspheres loaded with model drug, salicylate molecular, are prepared, and the dielectric spectroscopy of this kind of suspension is measured, meanwhile a significant relaxation is observed for the microspheres suspension. By the modeling analytic of the relaxation, the parameters, which can reflect the properties of microspheres and continuous medium, are obtained. Furthermore, the releasing process of microspheres in aqueous phase is monitored real-timely, namely, by analyzing the time-dependent variation of the parameters reflecting the relaxation characteristics and electrical parameters in each phase the releasing process is detected. The research shows that the controlled release process of chitosan microspheres loaded with salicylate in aqueous phase is divided into three phases according to different releasing mechanisms. At the release stage, the quantitative relation between the phase parameters obtained by dielectric analysis and the amount of the salicylate carried in microspheres was derived, and a real-time monitoring method was established through releasing material in the microspheres at different times obtained by measuring and analyzing the dielectric spectroscopy.The chitosan microspheres loaded with model drug, salicylate molecular, are prepared, and the dielectric spectroscopy of this kind of suspension is measured, meanwhile a significant relaxation is observed for the microspheres suspension. By the modeling analyric of the relaxation, the parameters, which can reflect the properties of microspheres and continuous medium, are obtained. Furthermore, the releasing process of microspheres in aqueous phase is monitored real-timely, namely, by analyzing the rime-dependent variation of the parameters reflecting the relaxation characteristics and electrical parameters in each phase the releasing process is detected. The research shows that the controlled release process of chitosan microspheres loaded with salicylate in aqueous phase is divided into three phases according to different releasing mechanisms. At the release stage, the quantitative relation between the phase parameters obtained by dielectric analysis and the amount of the salicylate carded in microspheres was derived, and a real-time monitoring method was established through releasing material in the microspheres at different times obtained by measuring and analyzing the dielectric spectroscopy.

关 键 词：壳聚糖微球 连续介质 监测方法 释放机制 药物 载药 释放过程 光谱测量 

分 类 号：TQ460.1[化学工程—制药化工]