竹红菌素及其衍生物敏化的生物膜和DNA结构的光损伤的Raman光谱研究  

Raman Spectroscopic Study of Structural Photodamage of Biomembrane and DNA Sensitized By Hypocrellin and Its Derivatives

作　　者：许以明[1] 张志义[1] 

机构地区：[1]中国科学院生物物理研究所

出　　处：《光散射学报》1998年第2期68-75,共8页The Journal of Light Scattering

基　　金：国家自然科学基金

摘　　要：本文综述了具有抗癌和抗艾滋病毒活性的三种光敏剂—竹红菌素及其衍生物敏化的生物大分子—生物膜和ＤＮＡ结构的光损伤的Ｒａｍａｎ光谱特征；上述三种光敏剂对ＤＮＡ和生物膜损伤最强的均为５－Ｂｒ－ＨＢ，其次是ＨＢ，然后是ＨＡ，即５－Ｂｒ－ＨＢ＞ＨＢ＞ＨＡ。说明药物的结构与它的光敏活性密切相关，修饰结构是增进药效的重要途径。It is summary of Raman spectroscopic characteristics of photodamage's biomembrane and DNA sensitized by three hypocrellin and its derivatives having anticancer and antivirus activities. Photosensitive damage on biomembrane and DNA sensitized by 5 Br hypocrellin B(HB) is stronger than that by hypocrellin A (HA) and hypocrellin B(HB), that is, 5 Br HB>HB>HA. It was indicated that the structure of drug is close related to its photosensitive activity and the modification of structure of drug is one of important path which improves efficience of drug.

关 键 词：竹红菌甲素 生物膜 DNA 光损伤 拉曼光谱 

分 类 号：R979.1[医药卫生—药品] O657.37[医药卫生—药学]