早发型重度子前期的临床特点及围产结局分析  

Perinatal Characteristics and Outcomes of the Early Onset Severe Preeclampsia

作　　者：匡德凤[1] 华绍芳[1] 韩玉环[1] 

机构地区：[1]天津医科大学第二医院产科,300211

出　　处：《天津医药》2010年第4期262-265,共4页Tianjin Medical Journal

基　　金：天津市应用基础及前沿技术研究计划(项目编号:09JCYBJC13000)

摘　　要：目的:探讨早发型重度子前期对妊娠结局的影响并探寻最佳的治疗方案,以减少并发症、改善围产结局。方法:回顾分析天津医科大学第二医院2007年1月—2008年12月收治的139例重度子前期患者(其中早发型重度子前期患者53例,晚发型重度子前期患者86例)及其围产儿139例的临床资料。分析指标包括一般情况、并发症及母婴结局。结果:早发型重度子前期患者分娩孕周较晚发型早(P<0.05),治疗时间较晚发型长(P<0.05),其临床并发症(胎死宫内、胎窘、胎盘早剥、子等)较晚发型严重(P<0.05),新生儿窒息率和围产儿病死率较晚发型患儿高(P<0.05)。结论:早发型重度子前期发病早、病情重,严重影响母婴预后,应根据母儿情况,严格选择病例进行保守治疗,同时密切监测母儿病情变化。Objective：To investigate the effect of early onset severe preeclampsia on pregnancy outcome and to explore the appropriate clinical management in order to improve the perinatal outcomes. Methods：One hundred and thirty-nine mothers with severe preeclampsia and their 138 neonates who were cured in The Second Hospital of Tianjin Medical University from January 2007 to December 2008 were retrospectively analyzed. There were 53 early-onset and 86 late-onset severe preeclampsia in 139 severe preeclampsia patients. The general condition of the mothers,complications and outcomes of both mothers and infants were surveyed. Results：The time of gestation termination was earlier in the cases of early onset severe preeclampsia than that of late-onset severe preeclampsia（P〈 0.05）. In addition,the time period of treatment was also longer in early onset severe preeclampsia than that of late-onset severe preeclampsia（P〈 0.05）. The early onset severe preeclampsia was more severe in patients with complications （dead fetus in uterus,fetal distress in uterus,placental abruption and eclampsia） than that of late-onset patients with severe preeclampsia （P〈 0.05）. Early-onset neonatal asphyxia and perinatal case-fatality rate was significantly higher in patients with early-onset than that in patients with late-onset. Conclusion：Compared with the late onset severe preeclampsia,the state of the early-onset severe was more severe,which would do more hazard to the maternal,fetus and neonatal. Obstetricians should select cases carefully for expectant treatment. Therefore a close monitoring of those mothers and infants is very important.

关 键 词：先兆子 妊娠并发症 窒息 新生儿 婴儿死亡率 

分 类 号：R714.43[医药卫生—妇产科学]