下呼吸道鲍曼不动杆菌感染及耐药性变迁  

Infection of Acinetobacter baumannii in lower respiratory tract and the variations of drug resistance

作　　者：蓝柳燕[1] 王君[1] 辜红妮[1] 林漫燕[1] 陈曼丹[1] 

机构地区：[1]汕头大学医学院第二附属医院检验科,515041

出　　处：《国际流行病学传染病学杂志》2010年第2期105-106,共2页International Journal of Epidemiology and Infectious Disease

摘　　要：目的 观察下呼吸道鲍曼不动杆菌感染及耐药性变化的趋势.方法 回顾性调查分析2005年1月至2008年12月本院分离自住院患者痰样本的鲍曼不动杆菌及其耐药性资料.结果在4年的痰检测样本中,共分离到鲍曼不动杆菌234株,占总体痰样本细菌检出率的8.5%.所有菌株均引起下呼吸道感染,对亚胺培南、美罗培南耐药率最低,分别为4%～9%和5%～6%,对其他抗生素均有较高的耐药率.结论 鲍曼不动杆菌感染以临床危重病患者（ICU、脑外科、烧伤科、呼吸内科）多见.大部分药物的鲍曼不动杆芮耐药率逐年上升.临床跃务人员应加强监测,并根据病原菌培养药敏结果选用敏感抗生素,规范抗生素应用,保持敏感抗生素的抗菌活性,以提高疗效和减缓耐药株的产生.Objective To investigate the infection of Acinetobacter baumannii in lower respiratory tract and the variations of trendency of drug resistance.Methods The data concerning Acinetobacter baumannii infection in our hospi-tal from January 2005 to December 2008 were retrospectively analyzed.Results Of all the sputum samples in 4 years,234 strains of Acinetobacter baumannii were isolated and the detectable rate was 8.5 %.All the strains caused lower res-piratory tract infection.The drug-resistance rate of imipenem（4%～9%）and meropenem（5%～6%）was the lowest among most of antibiotics,other antibiotics showed higher drug-resistance rate.Condusions The infections of Acineto-batter baumannii mainly happen in critical patients and most of the patients are in ICU,aural sursery departement,burns surgery department,respiratory medicine depariment.The drug-resistance rate of antibiotics shows an increasing trendency in recent years.Clinical staff should strengthen antibiotic resistance monitoring,choose antibiotics on the drug-sensitive results,standardize the drug use and improve the curative effect.

关 键 词：鲍曼不动杆菌 感染 抗生素 耐药性 

分 类 号：R446.5[医药卫生—诊断学]