冠心病患者血浆β内啡肽动态变化及其临床意义  

Changes and significance of plasma β-endorphin in patients with coronary heart disease

作　　者：肖继明[1] 徐军[1] 缪东培[1] 

机构地区：[1]南京军区南京总医院老年心脏病科,210002

出　　处：《江苏医药》2010年第7期766-768,共3页Jiangsu Medical Journal

摘　　要：目的探讨冠心病患者血浆β内啡肽(β-EP)水平动态变化及临床意义。方法动态检测急性心肌梗死(AMI)22例和心绞痛(AP)36例患者(冠心病组)血浆β-EP、血清肌钙蛋白T(cTnT)和肌酸激酶同工酶(CK-MB),并行超声心动图左心室舒张末期内径(LVEDD)、收缩末期内径(LVESD)和射血分数(LVEF)测定,临床心功能评定。其结果与20例健康体检者为对照组(C组)比较。结果冠心病组AMI发病、AP入院发作后12、24、48、96h及7d血β-EP、cTnT、CK-MB水平均显著高于C组(P<0.05);均于12h内开始升高,24h达峰值,7d内逐渐下降;三项指标均随心功能不全升级而升高。血β-EP与cTnT、CK-MB水平及LVEDD、LVESD呈正相关(P<0.05或P<0.01),与LVEF值呈负相关(P<0.05)。结论血浆β-EP水平可作为冠心病急性事件和心功能状况的辅助监测指标。Objective To study the dynamic changes and significance of plasma β-endorphin（β-EP）in the patients with coronary heart disease（CHD）.Methods The plasma levels of β-EP,cTnT and CK-MB were measured in 22 patients with acute myocardial infarction（AMI）and 36 patients with angina pectoris（AP）（group CAD）,in whom left ventricular ejection fraction（LVEF）,end-diastolic volume（LVEDD）and end-systolic volume（LVESD）were measured with echocardiography and the cardiac function was assessed.The results were compared with 20 healthy subjects（group C）.ResultsThe plasma levels of β-EP,cTnT and CK-MB were higher in group CAD than those in group C at 12,24,48,96h and on the 7th day after episode（P〈0.05）,which were rising in 12h,reaching peak level at 24h,and falling down in 7 days.The plasma level of β-EP was positively correlated to the levels of cTnT and CK-MB and the values of LVEDD and LVESD（P〈0.05 or P〈0.01）,but was negatively correlated with LVEF in 58 CHD patients（P〈0.05）.Conclusion The plasma level of β-EP may be taken as an assistant laboratory marker for assessment of acute events and cardiac function of CHD patients.

关 键 词：冠心病 Β内啡肽 

分 类 号：R541[医药卫生—心血管疾病]