异氟烷遗忘作用与γ-羟基丁酸受体的关系  

Relationship between γ-hydroxybutyric acid receptor and amnesia of isoflurane

作　　者：司振强[1] 张羽[1] 夏雪[1] 郭燕[1] 黄益波[1] 雍辉[1] 周慧轩[1] 周美艳[1] 戴体俊[1] 

机构地区：[1]徐州医学院,221004

出　　处：《江苏医药》2010年第7期796-798,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(30872432;30471657;39970715);江苏省自然科学基金(BK200143)

摘　　要：目的分析异氟烷遗忘作用与γ-羟基丁酸受体(GHBAR)的关系。方法建立异氟烷小鼠遗忘模型,跳台、避暗实验分别观察侧脑室注射不同剂量GHBAR阻断剂NCS-382对模型鼠潜伏期和错误次数的影响。结果NCS-382对异氟烷遗忘作用的影响无统计学意义(P>0.05)。结论GHBAR并非异氟烷遗忘作用的主要靶位。Objective To investigate the relationship between γ-hydroxybutyric acid receptor（GHBAR） and the amnesia of isoflurane.Methods After the establishment of mice learning and memory model by subcutaneous injection of appropriate doses of isoflurane,different doses of GHBAR antagonist NCS-382 were injected intracerebroventricularly and the effects on the latency period and the number of errors were observed.Results NCS-382 did not have any significant effects on isoflurance-induced amnesia（P〉0.05）.Conclusion GHBAR is not the main target position for isoflurance-induced amnesia.

关 键 词：异氟烷 NCS-382 学习记忆 Γ-羟基丁酸受体 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]