H_3PO_4/Zr(OH)_4高效促进NBS对取代烷基苯的亲电溴代  

Bromination of the Alkylbenzene Substrates with N-Bromosuccinimide/H_3PO_4/Zr(OH)_4

作　　者：阮礼波[1] 刘烽[1] 欧文华[1] 毛海舫[1] 潘仙华[1] 

机构地区：[1]上海应用技术学院香料香精技术与工程学院,上海200235

出　　处：《化学学报》2010年第7期713-716,共4页Acta Chimica Sinica

基　　金：上海市教委(No.0602004)资助项目

摘　　要：使用固体酸H3PO4/Zr(OH)4催化NBS对取代烷基苯进行苯环溴代反应.根据不同取代烷基苯的反应活性,在乙腈中,高产率(79%～96%)地得到了相应的苯环单溴代产物,同时反应体系中无苄位溴代的副产物生成.在反应过程中,固体酸催化剂可以重复使用多次.A new method of regioselective monobromination of the alkylbenzene substrates with N-bromosuccinimide promoted by solid acid H3PO4/Zr（OH）4 was developed.The reactions were smoothly carried out in CH3CN under reflux conditions to give monobromination products in excellent yields（79%～ 96%）.The brominated products of side chain were not observed.Remarkably,the catalyst of the solid acid H3PO4/Zr（OH）4 could be recycled and reused many times.

关 键 词：亲电溴代 固体酸 取代苯 

分 类 号：O621.255[理学—有机化学] O643.32[理学—化学]