串珠镰刀菌素(MON)及硒对中国小型猪关节软骨作用的实验研究  

The Experimental Study of Moniliformin and Selenium Effects on Articular Cartilage of Chinese Experimental Mini Pig

作　　者：熊咏民[1,2] 莫东旭[1,2] 李斯纯[1,2] 郭雄[1,2] 张矢远[1,2] 王治伦[1,2] 毕华银[1,2] 徐纪茹[1,2] 

机构地区：[1]西安医科大学地方性骨病研究所 [2]西安医科大学微生物免疫实验室

出　　处：《地方病通报》1998年第2期1-4,共4页Endemic Diseases Bulletin

基　　金：国家"八.五"攻关项目

摘　　要：中国实验用小型猪在低硒饲料（３５ｎｇ／ｋｇ）条件下，分别饲喂串珠镰刀菌素（１ｍｇ／ｋｇ体重）和硒（２００ｎｇ／ｋｇ饲料）三个月，观察动物前后肢软骨的病理变化及软骨基质中胶原及蛋白聚糖三组分含量的变化。结果表明串珠镰刀菌素对软骨组织具有较强的毒性作用，能致小型猪关节软骨深层发生类似人类大骨节病样的带状或片状坏死，并使软骨基质中蛋白聚糖含量降低，而单纯低硒并不能引起类似的损害。补硒能在一定程度上拮抗串珠镰刀菌素的毒性作用，使病变严重程度减轻。Moniliformin (1mg/kg body weight) and selenium (200ng/kg feed) were added Se-deficient feed containing selenium 35ng/kg for Chinese mini pigs in a period of three months. Pathologicol observations and biochemical analysis were carried out on the articular cartilage of those mini pigs. The results showed that there were obvious zonal and patchy chondronecrosis in the deep layer of articular cartilage in the moniliformin group, which was similar to the chondronecrotic lesions in the articular cartilage of human Kashin-Beck Disease. In addition, proteoglycans in the moniliformin group decreased compared with the control, however, such changes did not find in Se-deficient group. Selenium could alleviate the severity of the lesion and ameliorate the metabolism of proteoglycans to some extent.

关 键 词：串珠镰刀菌素 硒 大骨节病 动物实验 治疗 

分 类 号：R684.105[医药卫生—骨科学]