清银方治疗寻常型银屑病60例疗效观察及对血清IL-8的影响  

Observation of Qingyin prescription on psoriasis vulgaris and IL-8 in serum

作　　者：赵云夕[1] 芦红伟[2] 王根会[1] 冯兰珍[1] 

机构地区：[1]河北省中医院皮肤科,河北石家庄050011 [2]河北医科大学附属以岭医院儿科,河北石家庄050091

出　　处：《河北中医》2010年第3期333-334,共2页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察自拟清银方治疗寻常型银屑病的临床疗效及对血清白细胞介素8(IL-8)的影响。方法将120例寻常型银屑病患者随机分为2组,治疗组60例予自拟清银方,日1剂口服,对照组60例予以复方青黛胶囊口服。2组均连续治疗2个月。2组治疗前后进行PASI评分,计算病情改善率,评价疗效;采用放射免疫-饱和液相竞争法检测血清中IL-8水平。结果治疗组总有效率为83.3%,对照组总有效率为61.7%,2组总有效率比较差异有统计学意义(P<0.05)。2组治疗后与本组治疗前比较IL-8均明显降低(P<0.01);且治疗组较对照组降低明显(P<0.05)。结论自拟清银方对寻常型银屑病的疗效确切,且有显著的降低血清IL-8的作用。Objective To observe the effect of Qingyin prescription on psoriasis vulgaris and IL-8 in serum. Methods 120 patients with psoriasis vulgaris were randomly divided into control group, which was treated by Fufang Qingdai capsule, and treatment group, which was treated by Qingyin prescription. The course was two months in two groups. Before and after treatment, the improvement rate was evaluated by PASI score. The level of IL-8 was measured by radioimmunity - saturated liquid competition method. Results The total effective rate in treatment group （83.3%） was higher than that in control group （61.7%, P〈0.05）. The level of IL -8 in treatment group was lower than that in control group after treatment （ P 〈0.05）. Conclusion Qingyin prescription has definite effect on psoriasis vulgaris , and can decrease the level of IL -8.

关 键 词：银屑病 中医药疗法 白细胞介素8 胶囊剂(中药) 青黛 

分 类 号：R758.630.5[医药卫生—皮肤病学与性病学] R289.5[医药卫生—临床医学]