经直肠前列腺超声造影参数成像预测前列腺癌的临床研究  

Prediction of prostate cancer by contrast-enhanced transrectal ultrasound with parametric imaging

作　　者：费翔[1] 唐杰[1] 李岩密[1] 张艳[1] 石怀银[2] 

机构地区：[1]解放军总医院超声科,北京100853 [2]解放军总医院病理科,北京100853

出　　处：《军医进修学院学报》2010年第5期446-448,488,共4页Academic Journal of Pla Postgraduate Medical School

基　　金：国家自然科学基金资助项目(30772179)~~

摘　　要：目的评价经直肠前列腺超声造影参数成像对临床怀疑前列腺癌但超声没有发现明确病灶患者前列腺癌预测的临床应用价值。方法对30名血清PSA升高而灰阶超声没有发现明确病灶的患者在同天先后行经直肠前列腺超声造影及经直肠超声引导下前列腺穿刺活检的操作。造影图像切面选择在前列腺底部、中部及尖部与穿刺部位保持在同一切面,超声造影及穿刺活检由同一名医师承担。采用SonoProstate软件进行参数成像并分析造影参数图像。统计分析参数图像结果与病理结果。结果19例病理证实为前列腺癌的病例中参数成像方法诊断15例,11例病理证实为前列腺增生的病例中参数成像方法诊断9例。前列腺超声造影参数成像与超声引导下前列腺穿刺活检术对前列腺癌的预测无统计学差异(P=0.687)。结论对血清PSA升高但灰阶超声未发现明确前列腺病灶的患者,经直肠前列腺超声造影参数成像有助于提示前列腺癌可疑部位并指导前列腺穿刺活检。Objective To evaluate the application of contrast-enhanced transrectal ultrasound with parametric imaging in prediction of suspicious prostate cancer patients with no significant foci.Methods A total of 30 prostate cancer patients with increased PSA level but no foci in gray-scale ultrasound underwent contrast-enhanced transrectal ultrasound and biopsy of prostate on the same day.Contrast-enhanced transrectal ultrasound imaging at the base,middle and apex parts of prostate were observed and analyzed using the SonoProstate software.Results Of the 19 patients with pathology-confirmed prostate cancer,15 were diagnosed according to their imaging parameters.Of the 11 patients with pathology-confirmed prostate hyperplasia,9 were diagnosed according to their imaging parameters.No significant difference was found in parametric imaging of contrast-enhanced ultrasound and ultrasound-guided biopsy（P=0.687）.Conclusion Contrast-enhanced transrectal ultrasound with parametric imaging are helpful to find the suspicious areas of prostate cancer and direct biopsy in patients with increased PSA level but no significant foci.

关 键 词：前列腺癌 参数成像 超声造影 

分 类 号：R445.1[医药卫生—影像医学与核医学]