支气管激发试验后舒张试验在气道高反应性患者中的应用研究  

Application of Dilation after Bronchial Provocation Test in Bronchial Hyperresponsiveness

作　　者：方年新[1] 陈正贤[1] 吴欣[1] 

机构地区：[1]广东省人民医院(广东省医学科学院)呼吸内科,广东省广州市510080

出　　处：《中国全科医学》2010年第13期1418-1420,共3页Chinese General Practice

摘　　要：目的探讨支气管激发试验后舒张试验对支气管哮喘的诊断价值。方法对支气管激发试验阳性患者立即进行舒张试验,随访2年。结果97例患者中,56例临床确诊为支气管哮喘(哮喘组),余41例患者为非哮喘组。哮喘组舒张后第1秒钟用力呼气容积(FEV1)上升值和上升百分比高于非哮喘组,差异有统计学意义(P<0.05)。支气管激发试验后舒张试验FEV1改变率诊断支气管哮喘的ROC曲线下面积为0.76,支气管激发试验后舒张试验FEV1改变率最佳截点为18.24%,灵敏度为71.4%,特异度为73.2%。结论气道高反应性患者联合支气管激发试验后舒张试验可提高支气管哮喘诊断的特异度。Objective To investigate the diagnostic value of dilation test after bronchial provocation test to bronchial asthma. Methods Dilation test was carried out in patients with positive bronchial provocation test immediately and two - year followed up was conducted. Results In 97 patients 56 patients clinically diagnosed as having asthma were enrolled as asthma group, and the rest 41 as non - asthma group. FEV1 after dilation of patients in the asthma group showed an significant increase as compared with that in non - asthmatic group （ P 〈0. 05 ）. The area beneath the ROC curve of the per cent increase in FEV1 after dilation was 0.76, the optimal cut - off was 18.24% , the sensitivity was 71.4% and the specificity was 73.2% for diagnosing bronchial asthma. Conclusion The specificity for diagnosis of bronchial asthma in patients with bronchial hyperresponsiveness can be improved by combining positive bronchial provocation test with bronchial dilation test.

关 键 词：哮喘 气道高反应性 支气管舒张试验 支气管激发试验 

分 类 号：R562.25[医药卫生—呼吸系统]