气相色谱法测定微球制剂中二氯甲烷溶剂残留  

Measurement of dichloromethane residue in microsphere agent with gas chromatography method

作　　者：陈刚[1] 王玲[1] 宇博[1] 孟钢 

机构地区：[1]吉林大学测试科学实验中心,吉林长春130012 [2]长春百克生物科技有限公司,吉林长春130012

出　　处：《长春工业大学学报》2010年第1期94-96,共3页Journal of Changchun University of Technology

摘　　要：气相色谱法测定微球制剂中二氯甲烷溶剂残留。采用顶空气相色谱法,氢火焰离子化检测器(FID),以水做为溶剂,外标法,色谱柱采用HP-INNOWAX(30 m×0.32 mm×0.23μm)色谱柱。样品中二氯甲烷均未超过质量标准所规定的限度(不超过样品质量的0.5%),经方法学验证,该方法简单、灵活、重现性好,可很好地控制本品中二氯甲烷的有机溶剂残留。The dichloromethane residue in microsphere agent is tested by gas chromatography method.The headspace gas chromatography is applied with hydrogen flame ionization detector（FID） while water is used as solvent and HP-INNOWAX（30 m×0.32 mm×0.23 μm） as column.The dichloromethane residue in the samples does not exceed the standard（less than 0.5%）.It demonstrates that the method is simple,flexible and with good repeatability,which can be used to control dichloromethane residue in microsphere agent

关 键 词：气相色谱 二氯甲烷 微球制剂 有机溶剂残留 

分 类 号：O656.31[理学—分析化学] O657.71[理学—化学]