元宝草抗抑郁活性部位筛选研究  

Studies on Fractions with Antidepressant Activity from Hypericum Sampsonii Hance

作　　者：石金城[1] 闫显光[1] 刘媛[1] 夏超[1] 张惠云[2] 魏盛[2] 李自发[2] 祁超[3] 张桂森[3] 

机构地区：[1]南京工业大学,江苏省药物研究所,江苏南京210009 [2]山东中医药大学实验动物中心,山东济南250355 [3]江苏恩华药业股份有限公司,江苏徐州221002

出　　处：《辽宁中医药大学学报》2010年第5期7-9,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：江苏省药物所-江苏恩华药业新药研究联合实验室项目

摘　　要：目的:筛选元宝草提取物抗抑郁活性部位并初步了解其抗抑郁作用机制。方法:将元宝草提取物萃取分为5个不同的部位,应用4个抗抑郁药理模型筛选抗抑郁活性部位。结果:0804各剂量组均可以增加大鼠成功逃避次数,减少悬尾小鼠不动时间;0805中、小剂量组可以抑制利血平引起的小鼠体温降低;0801、0802、0805各剂量组,均可以显著抑制阿朴吗啡所致的小鼠体温降低。结论:元宝草提取物正丁醇萃取部分和水层部分均显示有较好的抗抑郁作用,初步机理探索提示元宝草提取物抗抑郁作用与去甲肾上腺素(NA)和多巴胺(DA)受体关系密切。Objective：Screen the antidepressant fractions of Hypericum sampsonii Hance and preliminary understand its mechanism of antidepressant.Methods：Extract Hypericum sampsonii Hance into five different fractions,screen the five fractions using four antidepressant pharmacological models.Results：Each dose group of 0804 can increase the escape numbers of mice,Shorten immobility time of mice in the tail suspension test;0805 Small and medium dose groups can reverse the body temperature declining induced by Reserpine in mice;Each dose group of 0801,0802,0805 can significantly inhibited body temperature declining induced by emetomorphine in mice.Conclusions：Water and n-butanol fractions of Hypericum sampsonii Hance extracts have shown remarkable antidepressant activity,the initial study on the mechanism show that the antidepressant effect of Hypericum sampsonii Hance has close relation with noradrenaline and dopamine receptor.

关 键 词：元宝草 抗抑郁 药效学筛选 

分 类 号：R284[医药卫生—中药学]