发形霞水母触手提取物对大鼠离体心脏传导系统的影响  

Effects of tentacle-only extract from jellyfish Cyanea capillata on the conduction system of isolated rat heart

作　　者：蔡滨欣[1] 郭玉峰[1] 张智[1] 肖良[1] 张黎明[1] 

机构地区：[1]第二军医大学海医系防化医学教研室,上海200433

出　　处：《药学实践杂志》2010年第2期112-113,125,共3页Journal of Pharmaceutical Practice

基　　金：全军"十一五"专项项目(06Z020);上海市自然科学基金(06ZR14111)

摘　　要：目的观察水母触手提取物(TOE)对大鼠离体心脏传导功能的影响,探讨其心脏毒性可能的作用机制。方法72只SD雄性大鼠随机分为6组(n=12),利用大鼠离体心脏Langendorff模型,分别给予不同剂量的TOE,观察其对大鼠心脏传导系统的影响。结果给予TOE后,与空白组比较,心率减慢和心律失常的几率明显增大,并呈现剂量依赖性。结论TOE对心脏的传导系统具有显著影响,是其心脏毒性的原因之一。Objective To observe the effects of tentacle-only extract（TOE） from Cyanea capillata on the conduction system of isolated rat heart and investigate the mechanism of its cardiac toxicity.Methods Seventy-two Sprague Dawley（SD） rats were randomly divided into six groups（n=12）,and Langendorff heart perfusion models were established,then different doses of TOE were applied to each group to observe the effects of TOE on the conduction system of the isolated rat hearts.Results Compared with the control group,all the doses of TOE induced a significant decrease of heart rate,and the incidence of arrhythmia was significantly increased.Moreover,both the effects were dose-dependent.Conclusion The TOE of C.capillata induced significant changes of the conduction system of isolated rat heart,which could partly interpret the mechanism of its cardiac toxicity.

关 键 词：水母毒素 离体心脏 传导系统 

分 类 号：R965[医药卫生—药理学]