生物学焦域的概念及在高强度聚焦超声切除组织中的作用  

Concept of Biological Focal Field and Its Importance in Tissue resection with High Intensity Focused Ultrasound

作　　者：王智彪[1] 伍烽[1] 王芷龙[1] 邹建中[1] 陈文直[1] 刘川[1] 杜永洪[1] 陈迅[1] 阮祥燕[1] 孔繁斌[1] 胡凯[1] 齐家俊 童艺[1] 王志刚[1] 

机构地区：[1]重庆医科大学医学超声工程研究所,400046

出　　处：《临床超声医学杂志》1998年第4期217-218,共2页Journal of Clinical Ultrasound in Medicine

摘　　要：本实验研究和比较了高强度聚焦超声(HIFU)所致体内深部组织凝固性坏死灶的形状和大小.结果显示参照同样的治疗参数,HIFU所致凝固性坏死灶的大小和形状在体内和体外有较大的差异.体内体积与治疗参数、靶组织的结构、功能和运动有密切关系.与物理学焦域比较,凝固性坏死灶体积亦可能命名为HIFU的生物学焦域.In this research the shape and size of necrosed tissue volume produced by HIFU with ].6MHz focused transducer were carefully checked and compared in pigs. This volume was generated by a single exposure. It was showed that with the same therapeutic parameters, HIFU could selectively necrose one region of liver in pigs. However, its shape and size differed between in vitro and in vivo. These changes implied that the necrosed tissue volume in vivo depended upon not only HIFU conditions, but also the function state, blood perfusion, function, and movement of target tissue. In contrast with physical focal region, necrosed tissue volume in vivo could also be termed the biological focal field of HIFU. Theoretically, it more resembled the living tissue damaged by HIFU. In order to avoid side effects, it is important to set up the data about biological focal fields of different organs in tissue resection with HIFU.

关 键 词：高强度聚焦超声 坏死灶 生物学焦域 HIFU 

分 类 号：R312[医药卫生—基础医学]