自微乳载药系统(SMEDDS)用于丹参酮的增溶及吸收研究  

Self-microemusifying drug delivery system increasing solubility and intestnum absorption in situ of tanshinones

作　　者：汪圣华[1,2] 赵姗[1] 杨荣平[1,3] 吕国军[1] 王云红[4] 谢威扬[1] 马小军[1] 

机构地区：[1]中国科学院大连化学物理研究所,辽宁大连116023 [2]中国科学院研究生院,北京100049 [3]重庆市中药研究院,重庆400065 [4]成都中医药大学,四川成都611731

出　　处：《中国中药杂志》2010年第9期1119-1122,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金重点项目(20736006);中国科学院知识创新工程重要方向项目(KJCX2-YW-210-02);中国科学院支持天津滨海新区建设科技行动计划项目(TJZX2-YW-14);重庆市自然科学基金重点项目(CSTC2009BA5034)

摘　　要：目的:考察自微乳载药系统(SMEDDS)对丹参酮的增溶和吸收的影响,以指导丹参酮SMEDDS处方的选择。方法:紫外分光光度法测定SMEDDS溶液中丹参总酮的溶解度,采用大鼠在体小肠吸收模型考察丹参酮SMEDDS的吸收。结果:丹参总酮在SMEDDS溶液中的溶解度是水中的10倍,胶束中的2.5倍,且SMEDDS处方中油相(中链甘油三酸酯,MCT)比例增加,溶解度增加;丹参酮SMEDDS和胶束的吸收常数Ka分别为0.479,0.326h-1,t1/2分别为1.44,2.12h,SMEDDS处方中油相(MCT)比例增加,吸收增加。结论:SMEDDS能显著增加丹参酮的溶解度和在大鼠小肠的吸收,且SMEDDS处方中MCT能促进丹参酮的增溶和吸收。Objective： Study the effect of self-microemusifying drug delivery system （SMEDDS） on the solubility and absorption of tanshinones to guide the selection of composition of tanshinone SMEDDS. Method ： The solubility of tanshinones in the solution of SMEDDS was determined by UV-spectrometer and the absorption of tanshinone SMEDDS was determined by HPLC as the detection method. Result： The solubility of tanshinones in solution of SMEDDS was 10 times in water and 2. 5 times in micelle solution. The solubility of tanshinones in solution of SMEDDS was increased with the increasing of oil（MCT） in composition of tanshinone SMEDDS. The absorption constants （Ka ）in SMEDDS and micelle solution was 0. 479 h^-1 and 0. 326 h^-1 respectively, and the absorption half life（ t1/2 ） was 1.44 h and 2. 12 h respectively. The absorption was increased with the oil increasing in composition of tanshinone SMEDDS. Conclusion： SMEDDS can increase the solubility and absorption of tanshinones significantly and the increasing of oil content （MCT） in SMEDDS composition promote the dissolution and absorption of tanshinones.

关 键 词：自微乳载药系统 丹参酮 增溶 吸收 

分 类 号：R285[医药卫生—中药学]