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作 者:龙福泉[1] 王千秋[1] 杨凭[1] 杨立刚[2] 彭华[3] 张森淼[3] 刘巧 张择榕 何玲 王海英[7]
机构地区:[1]中国医学科学院北京协和医学院皮肤病研究所中国疾病预防控制中心性病控制中心,江苏南京210042 [2]广东省皮肤性病防治中心,广州510500 [3]惠州市皮肤病医院,广东惠州516001 [4]海南省皮肤病医院,海口570206 [5]三亚市慢性病防治院,海南三亚572000 [6]琼海市皮肤性病防治所,海南琼海571400 [7]杭州市余杭区疾病预防控制中心,浙江余杭311100
出 处:《中国艾滋病性病》2010年第2期120-122,共3页Chinese Journal of Aids & STD
基 金:科技部科研院所社会公益研究专项基金(2005DIB1J096)~~
摘 要:目的报告并分析2007年1月至2008年12月,惠州、三亚、琼海、余杭四个城市,部分疑似先天梅毒的血清学结果并追踪观察。方法对四地市就诊的63例疑似先天梅毒婴儿进行干预及随访,检测其梅毒螺旋体明胶凝集试验(TPPA)和快速血浆反应素试验(RPR)及其滴度,对结果进行统计学分析。结果63例疑似先天梅毒婴儿TPPA均阳性,RPR滴度从阴性到1∶64;共有42例接受了青霉素治疗,其中18例随访3-12个月,15例显效,显效比例为88.33%;21例未做治疗,采取观察,其中9例随访3个月,显效比例为22.22%。采取"观察"者的效果不如"治疗"者,两者比较差异有统计学意义(P<0.01)。结论出生后如能及时给予青霉素治疗,可有较好的治疗效果;对疑似先天梅毒病例进行定期随访是非常重要的。当前工作中还有很多不足,应该提高随访率、随访次数和随访时间,加强对医务人员规范诊疗的培训。Objective To analyze the follow-up results of suspected congenital syphilis cases in cities of Huizhou, Sanya, Qionghai and Yuhang from January 2007 to December 2008. Methods Sixty-three suspected congenital syphilis cases in the four cities were followed up by detecting TPPA and RPR titers. The results were analyzed by statistical software SPSS 13.0. Results All 63 cases with suspected congenital syphilis were TPPA positive, and the RPR titer ranged from negative to 1:64, of which 27cases were followed up for one to four times, and the rate of follow-up was relatively high in two cities of Hainan province ( i.e. Sanya and Qionghai ). Forty-two cases were treated with penicillin, of which 18 cases were followed up for 3-12 months and 15 cases reported significant improvement with a rate of marked efficacy of 88.33% , while 21 cases were not treated ,of which 9 cases were followed up for 3 months, with a rate of marked efficacy of 22.2% The rate of improvement after the treatment was 62.96%. The treated cases were more likely to achieve improvement than those without treatment (χ^2=7.14, P〈0.01). Conclusions Treatment with penicillin promptly after birth will lead to a better efficacy, and regular follow up for infants of suspected congenital syphilis will play a very important role . It is suggested that health care providers be trained in standardized management of suspected congenital syphilis in order to increase the rate, frequency and duration of follow-up.
分 类 号:R759.1[医药卫生—皮肤病学与性病学]
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