基于环糊精的分子印迹技术  

Molecular Imprinting Technology Based on Cyclodextrins

作　　者：孙涛[1] 李媛媛 张华承[1] 郝爱友[1] 

机构地区：[1]山东大学化学与化工学院,济南250100

出　　处：《化学进展》2010年第5期888-897,共10页Progress in Chemistry

摘　　要：基于环糊精的分子印迹技术综合了超分子化学、高分子化学、分析化学等多学科优势,对人为可控的大型超分子主体化合物的合成有着指导意义,对具有多位点识别人工酶的实现也有巨大的推动作用。本文首先介绍了不同种类的基于环糊精的分子印迹产物的合成,包括合成思路、步骤、方法以及识别机理探讨;然后着重叙述了该体系的应用研究进展,包括其在分子识别、色谱分离、电化学传感器以及生物学控制等领域的应用;最后指出目前研究工作存在的不足,并对其发展前景进行了展望。Molecular imprinting technology, as an interdisciplinary field which developed recently, is applied widely in many areas. Cyelodextrins are cyclic oligosaccharides, and have proper rigidity and flexibility, excellent mechanical stability and biocompatibility. Cyclodextrins have the ability to form inclusion complexes with a wide range of substrates for their particular structures, which makes cyclodextrins as good choice of materials in molecular imprinting technology. Composing of the advantages of supramolecular chemistry, maeromolecular chemistry and analytical chemistry, molecular imprinting technology based on cyelodextrins is of great guiding significance for the synthesis of artificially controlled host molecules in supramolecular chemistry and the realization of artificial enzyme with multi-recognition sites. Here, the recent development of molecular imprinting technology based on eyclodextrins is reviewed. Firstly, the synthesis of different kinds of products of molecular imprinting technology is introduced, including the synthesis clues, approaches, methods and the recognition mechanism. Then, the applications of the system in the fields of molecular recognition, chromatographic separation, electrochemical sensors and biological control are emphatically described. At last, the disadvantages in recent study and prospects are pointed out.

关 键 词：环糊精 分子印迹技术 聚合环糊精 分子识别 

分 类 号：O629.12[理学—有机化学] O631[理学—化学]