肺栓塞患者血小板膜糖蛋白相关基因mRNA显著性差异表达的意义  

Expression Profile of Platelet Associated Genes in Patients with Pulmonary Thromboembolism(PTE)

作　　者：王嫱[1] 王乐民[1] 龚朱[1] 郜恒骏[2] 沈晓莹[2] 

机构地区：[1]上海同济大学附属同济医院心血管内科,上海200065 [2]生物芯片上海国家工程研究中心

出　　处：《微循环学杂志》2010年第2期1-4,F0003,共5页Chinese Journal of Microcirculation

基　　金：国家自然科学基金资助项目(NO:30570809)

摘　　要：目的:研究血小板膜糖蛋白在静脉血栓形成过程中的作用。方法:基因表达谱芯片检测肺栓塞(PTE)组与对照组血小板膜糖蛋白相关基因的mRNA表达水平及其差异。结果:PTE组血小板膜糖蛋白相关因子的mRNA表达与对照组显著差异(P<0.05)者只占所测基因的45.45%。结论:血小板膜糖蛋白相关因子mRNA表达的差异性提示在静脉血栓形成过程中,血小板仅发挥少部分功能,支持了临床大规模试验所述的不提倡单独应用抗血小板药物治疗和预防静脉血栓性疾病的结论。Objective:To study the effect of platelet membrane glycoprotein in the process of venous thrombosis.Method:Gene expression chip was used to detect the difference of relative factors of platelet membrane glycoprotein between PTE patients and control group.Results:The factors having significant difference(P<0.05)between PTE patients and control group account 45.45% of all the factors tested.Conclusion:The mRNA expression of significant differences of platelet membrane glycoprotein indicates that platelet plays limited part of the functions during the process of PTE,which supports the conclusion of large-scale clinical trail that antiplatelet drugs alone can not cure or prevent venous thrombosis effectively.

关 键 词：血小板膜糖蛋白 基因MRNA 差异表达 肺动脉血栓栓塞症 深静脉血栓形成 肺栓塞 静脉血栓栓塞症 患者 

分 类 号：R543.2[医药卫生—心血管疾病] Q78[医药卫生—内科学]