卡托普利对压力负荷增加大鼠血浆血管紧张素Ⅱ、心钠素及醛固酮水平的影响  

Effects of Captopril on the Expression of Plasma Angiotensin Ⅱ,Atrial Natriuretic and Aldosterone in Rats with Pressure Overload

作　　者：董晓蕾[1] 张群燕[1] 赵智明[1] 郭郡浩[1] 张永文[1] 蔡辉[1] 

机构地区：[1]南京军区南京总医院中西医结合科,南京210002

出　　处：《微循环学杂志》2010年第2期5-6,10,F0004,共4页Chinese Journal of Microcirculation

基　　金：中国人民解放军南京军区南京总医院科研基金资助项目(NO:Q2008042)

摘　　要：目的:观察卡托普利对压力负荷增加大鼠血浆血管紧张素Ⅱ(AngⅡ)、心钠素(ANP)及醛固酮(ALD)水平的影响,探讨卡托普利对左室重构的干预机制。方法:清洁级雄性SD大鼠36只随机分为3组:假手术组、模型组、卡托普利组,每组12只。采用放射免疫分析法检测血浆AngⅡ、ANP及ALD水平,观察左室重量指数(LV-MI)变化。结果:模型组LVMI明显高于假手术组(P<0.01);血浆AngⅡ、ANP、ALD水平较假手术组显著升高(P<0.01)。与模型组比较,卡托普利组血浆AngⅡ、ANP、ALD水平及LVMI均明显下降(P<0.01,P<0.05)。结论:压力负荷增加所致左室重构的作用可能与血浆AngⅡ、ANP及ALD水平升高有关。卡托普利可降低压力负荷增加大鼠血浆AngⅡ、ANP及ALD水平;延缓或对抗左室重构的发生发展。Objective:To explore the effects of captopril on the expression of plasma angiotensinⅡ(AngⅡ),atrial natriuretic polypeptide(ANP)and aldosterone(ALD)in rats with pressure overload.Method:36 SD male rats were randomly divided three groups:sham operation group,model group,captopril group,with twelve rats in each group.Left ventricular mass index(LVMI),AngⅡ,ANP,ALD were measured in each group.Results:LVMI level in the model group was obviously higher than that of the sham group(P<0.05);compared with the model group,the level of plasma AngⅡ,ANP,ALD were decreased significantly(P<0.01,P<0.05).Conclusion:The levels of plasma AngⅡ,ANP and ALD were increased in rats with myocardial hypertrophy of congestion heart failure by pressure overload increased.The mechanism of the left ventricular remodeling might be related with the levels of plasma AngⅡ,ANP and ALD.Captopril had the effects on decreasing the level of plasma AngⅣ,ANP,ALD in rat with pressure overload.It maybe concern with redress of circulating endocrine disorder that captopril regress left ventricular remodeling.

关 键 词：血浆血管紧张素Ⅱ 压力负荷增加大鼠 卡托普利 心钠素 醛固酮水平 肾素-血管紧张素-醛固酮系统 充血性心力衰竭 神经体液因素 

分 类 号：R542.2[医药卫生—心血管疾病]