妊娠期肝内胆汁淤积症血清甘胆酸水平对孕妇及胎儿的影响  

Effects of serum bile acid level in intrahepatic cholestasis of pregnancy on pregnant women and fetuses

作　　者：马少平[1] 张轶清[1] 周毅惠[1] 

机构地区：[1]皖南医学院附属弋矶山医院妇产科,安徽芜湖241001

出　　处：《皖南医学院学报》2010年第2期106-108,共3页Journal of Wannan Medical College

摘　　要：目的:探讨甘胆酸水平对妊娠期肝内胆汁淤积症(ICP)母婴结局的影响。方法:对我院2007年1月～2008年12月共102例ICP患者临床资料进行回顾性分析,按照终止妊娠前血清甘胆酸水平分为≥86nmol/L组和<86nmol/L组,分析统计母婴并发症的发生情况。结果:两组间围生儿并发症比较P<0.05,差异有统计学意义;治疗前后孕妇肝功能比较P<0.05,差异有统计学意义。结论:高水平甘胆酸严重影响母婴预后,加强胎儿监护,适时终止妊娠是关键。Objective：To explore the relationship of bile acid level and its effects on patients with intrahepatic cholestasis of pregnancy（ICP）and fetuses.Methods：The clinical data were retrospectively analyzed in 102 ICP patients between Jan.2007 and Dec.2008,and all subjects were divided into group A（≥86 nmol/L）and group B（〈86 nmol/L）according to serum bile acid level before termination of pregnancy.The incidence rate of serious complication of perinatal stage and pregnancy was observed and analyzed statistically.Results：The two groups were significantly different in statistics concerning the perinatal complications（P〈0.05）and variation of the liver function in patients before and after intervention（P〈0.05）.Conclusion：The higher bile acid level may lead to poor prognosis in ICP patients.The effective measures should be intensive care of the fetuses and early termination of pregnancy.

关 键 词：妊娠期肝内胆汁淤积 甘胆酸 

分 类 号：R714.255[医药卫生—妇产科学]