神经痛的药物作用靶点及其机制  

The drug targets and their mechanisms against neuropathic pain

作　　者：曾娴婷[1] 张春秀[1] 肖华胜[1] 

机构地区：[1]上海生物芯片有限公司生物芯片上海国家工程研究中心,上海201203

出　　处：《沈阳药科大学学报》2010年第5期412-418,共7页Journal of Shenyang Pharmaceutical University

基　　金：国家"863"计划资助项目(2006AA020704);上海市科委资助项目(09DZ1905000)

摘　　要：目的对近年来出现的治疗神经痛的药物作用靶点及其机制作以综述。方法在查阅30篇文献的基础上,对神经痛的治疗靶点进行整理和归纳。结果目前治疗神经痛的药物作用靶点主要有5-羟色胺受体、去甲肾上腺素受体、阿片受体、大麻素受体、离子通道、免疫相关物质等等。以这些靶点设计的药物均已证明可在一定程度上缓解神经痛。结论为进一步开发治疗神经痛的靶向药物提供参考。Objective To review the drug targets and their mechanisms against neuropathic pain in recent years.Methods Based on 30 references,the targets of treating neuropathic pain were classified.Results The drug targets against neuropathic pain included 5-HT receptor and nor adrenaline receptor,opiate receptor and cannabinoid receptor,ion channel,immune related substances and so on.It had been proved that the targeted medicines could relieve neuropathic pain to some degree.Conclusions The paper can provide some suggestions for drug discovery against neuropathic pain.

关 键 词：神经痛 受体 通道 药物 

分 类 号：R962[医药卫生—药理学]