新型动脉瘤动物模型的建立及彩色多普勒评价  

Construction of A New Type of Rabbits' Aneurysmal Models and Evaluation with Color Doppler

作　　者：李淼[1] 杨新健[2] 史万超[3] 王捷[1] 吕明[2] 穆士卿[2] 张莹[2] 高宇飞[1] 赵丛海[1] 

机构地区：[1]吉林大学中日联谊医院,吉林长春130033 [2]北京市神经外科研究所 [3]解放军307医院

出　　处：《中国实验诊断学》2010年第5期633-636,共4页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金资助项目(30772234);北京市自然科学基金资助项目(7072016);北京市优秀人才培养资助个人项目(20061D0300400072);首都医科大学基础临床合作课题资助项目(2007JL39)

摘　　要：目的建立形态、病理、行为表现及血流动力学特点都更加逼真的动脉瘤动物模型,并应用彩色多普勒对动脉瘤模型进行评价。方法采用新西兰大白兔16只,应用显微缝合法制作侧方动脉瘤模型8只,顶端动脉瘤模型8只。分别于动脉瘤建立后即刻和2周测量动脉瘤的直径,并于2周后行彩色多普勒测定载瘤动脉及动脉瘤内血流速度。结果共制作侧方动脉瘤模型8个,顶端动脉瘤模型8个,其中顶端动脉瘤模型有1枚动脉瘤模型建立术后24小时破裂,1枚动脉瘤术后2周破裂。2周后行彩色多普勒检查发现载瘤动脉血流速度较动脉瘤内血流速度快,动脉瘤内为双向等速涡流血流。结论经弹力酶和胶原酶处理新型兔动脉瘤模型,为动脉瘤的血流动力学研究提供了坚实基础。彩色多普勒成功应用于动脉瘤模型的评价,成为动脉瘤血流动力学研究新的辅助工具。Objective We produce lateral and terminal aneurysmal models which are more similar to clinical counterparts in morphology,pathology,and behavior,and evaluate the models with color Doppler.Methods Sixteen white rabbits were utilized.We form eight lateral aneurysmal models and eight terminal aneurysmal models models with Micro-suture.The diameters were measured just after the construction and 2 weeks after the construction of the models.And after 2 weeks the blood velocity in the aneurismal models and their parent arteries were measured with color Doppler.Results Eight lateral aneurysmal models and eight terminal aneurysmal models models were produced.One terminal aneurysmal model ruptured in 24 hours after the construction,the other terminal aneurysmal model ruptured in 2 weeks after the construction.After 2 weeks with color Doppler,we can find the blood velocity in their parent arteries is higher than in the aneurismal models.The blood fluid in the aneurismal models is the double-direction and constant velocity.Conclusion This kind of aneurismal model is the basic of the study of hemodynamics.The color Doppler is used to evaluate the models successfully,and it become a new tool in the study of the aneurysmal hemodynamics.

关 键 词：动脉瘤 动物模型 神经外科 彩色多普勒 

分 类 号：R651.1[医药卫生—外科学] R-332[医药卫生—临床医学]