普贝生用于足月妊娠羊水偏少引产临床研究  

Clinical Evaluation of Propess on Induction of Labor in Gravida with Borderline Oligohydramnios

作　　者：李云[1] 胡艳[1] 马喆[1] 

机构地区：[1]北京大学深圳医院妇产科,518036

出　　处：《青海医药杂志》2010年第3期1-3,共3页Qinghai Medical Journal

摘　　要：目的:探讨地诺前列酮栓剂(普贝生)用于足月妊娠羊水偏少病例引产的有效性和安全性。方法:采用随机对照前瞻性研究方法,对正常单胎头位足月妊娠羊水偏少,排除头盆不称,无各种妊娠合并症及并发症而无前列腺素、缩宫素禁忌症的孕妇82例,随机分成普贝生观察组(42例);催产素对照组(40例),比较两组的宫颈评分改善、临产开始时间、阴道分娩率、总产程、产后24小时出血量和新生儿Apgar评分及以及出现子宫过度刺激等情况的差异。结果:用药后普贝生组42例宫颈评分显著改善,仅2例无改善,总有效率为95.23%,用药至临产时间(10.48±6.44)h,总产程(5.69±2.4)h,阴道分娩率85.71%;缩宫素组22例宫颈评分有不同程度的改善,总有效率为(55.00%),临产时间(29.±12.21)h,总产程(11.30±3.09)h,阴道分娩率40.00%,P<0.01。普贝生引产促宫颈成熟有效率高,进入产程快,产程短,阴道分娩率高,剖宫产率低,两组产后出血量及新生儿Apgar评分无显著性差异。结论:普贝生用于足月妊娠羊水偏少引产安全有效,能显著提高阴道分娩率,降低剖宫产率。Objective：To discuss the effectiveness and safety of Dinoprostone Suppositories（Propess）in induction of labor for gravida with borderline oligohydramnios. Methods：A toal of 82 gravida women with borderline oligohydramnios,no subjects had evidence of cephalopelvic disproportion,pregnancy complication and contraindication for prostaglandin and oxytocin,were divided randomdly into the Propess group（n=42） and the oxytocin control group（n=40）. We compared the differeces in amelioration of cervical score,starting time in labor,vaginal delivery rate,total stage of labor,amount of postpartum bleeding,Apgar score and over intensity uterine contraction between the two groups.Results：The cervical score were improved in propess group,the total effective rate in the propess group and the control group is95.23% and 55.00% respectively; and the average time from medication to in labor was 10.48±6.44h and 29.±12.21h respectively; the total stage of labor was （5.69±2.40）h and （11.30±3.09）h respectively,the vaginal delivery rate was 85.71% and 40.00% （P〈0.01） respectively. The improvement of cervical score was better in the propess group than that in the control group. There was no statistical difference in amount of postpartum bleeding and Apgar score between the two groups. Conclusions：Propess could induce labor safely,and improve vaginal delivery rate and decrease Cesarean section rate in gravida with borderline oligohydramnios.

关 键 词：普贝生 缩宫素 引产 足月妊娠 羊水偏少 

分 类 号：R719.3[医药卫生—妇产科学] R714.43[医药卫生—临床医学]