广西不同人群庚型肝炎病毒感染状况的调查  

Investigation of HGV infection in various populations in Guangxi.

作　　者：茹海匀[1] 温小凤[1] 梁伟屏[1] 朱汝洁[1] 

机构地区：[1]柳州市人民医院

出　　处：《中华实验和临床病毒学杂志》1998年第4期336-339,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的了解庚型肝炎病毒（ＨＧＶ）感染在广西柳州地区不同人群中的感染状况，并比较静脉毒瘾者与健康体检者ＨＧＶ、乙型肝炎病毒（ＨＢＶ）、丙型肝炎病毒（ＨＣＶ）与ＨＧＶ共同感染的特点。方法应用酶联免疫法（ＥＬＡ）检测抗－ＨＧＶ、抗－ＨＣＶ、ＨＢＶＭ（ＨＢｓＡｇ、ＨＢｓＡｂ、ＨＢｅＡｇ、ＨＢｅＡｂ、ＨＢｃＡｂ），并对抗－ＨＧＶ阳性者随机抽取２０例（１９％）进一步用逆转录套式ＰＣＲ（ＰＴ－ｎＰＣＲ）法检测ＨＧＶＲＮＡ。结果该人群中抗－ＨＧＶ阳性率为９８％（１０６／１０７９），在肝硬变、静脉毒瘾者、反复输血及血制品和血液病者、肝癌、病毒性肝炎、血液透析者、健康体检者、职业献血员、健康孕妇等不同人群中，抗－ＨＧＶ阳性检出率分别为２３８％（５／２１），２１１％（２３／１０９），１２５％（６／４８），１２０％（６／５０），１２０％（２０／１６６），９３％（３／３２），８２％（３４／４１３），４３％（６／１４０），３０％（３／１００）。ＨＧＶ、ＨＢＶ、ＨＣＶ感染率在静脉毒瘾者中分别为２１２％（２３／１０９），７５３％（８２／１０９）及７３％（８／１０９），在健康体检者中分别为８３％（９／１０９），２０?In order to understand the situation of HGV infection in various populations in Liuzhou prefecture of Guangxi, Zhuangzu Autonomous Region, and also to compare the HGV, HBV, HCV infections between intravenous drug abusers and healthy persons (those for physical examination, the same below), the anti -HGV, -HCV and HBVM (HBsAg, HBsAb, HBeAg, HBeAb, HBcAb) were detected by ELA and,besides, tested further the 20 anti-HGV seropositive cases for HGV-RNA by RT-nPCR. The results showed that in the populations tested, the HGV seropositive rate was 9.8%(106/1079), separately they were 23.8%(5/21), 21.1%(23/109), 12.5%(6/48), 12.0%(6/50), 12.0%(20/166), 9.3%(3/32), 8.2%(34/413), 4.3%(6/140), and 3.0%(3/100) in liver cirrhosis, intravenous drug abusers, repeated blood and blood products transfused patients, hepatocellularcarcinoma patients, viral hepatitis, haemodialysis patients, healthy persons, paid blood donors and healthy pregnant women respectively. In intravenous drug abusers, the HGV, HBV, HCV infection rate were 21.2%(23/109), 75.3%(82/109) and 7.3%(8/109) respectively, while they were 8.2%(9/109), 20.1%(22/109), and 1.8%(2/109) in healthy persons respectively. These data showed that Liuzhou prefecture of Guangxi was HGV high epidemic area, HGV infection rate was higher in populations of intravenous drug abusers, viral hepatitis, liver cirrhosis and repeatedly blood and blood products transfused patients, even in pregnant women the HGV infection also occurred. There was a significant difference of HGV, HBV, HCV infection rates between intravenous drug abusers and healthy persons (P<0.005).

关 键 词：HGV HBV 流行病学 HCV 庚型肝炎 

分 类 号：R373.21[医药卫生—病原生物学]