血清胱抑素C与健康人颈动脉斑块的关系  

Correlation analysis between carotid plaque and serum cystatin C in healthy adults

作　　者：谷红霞[1] 孙雪峰[1] 张彬[1] 傅博[1] 黄大伟[1] 杨聚荣[1] 陈香美[1] 

机构地区：[1]解放军总医院全军肾病研究所暨肾病重点实验室,北京100853

出　　处：《中国老年学杂志》2010年第8期1026-1029,共4页Chinese Journal of Gerontology

基　　金：国家重大基础研究规划"973"项目资助(2007CB507405)

摘　　要：目的探讨健康人血清胱抑素C(CysC)与无症状颈动脉斑块的关系。方法以随机整群抽样方式在北京15个社区通过问卷调查、检测血清CysC、常规及生化指标及体格检查、颈动脉超声及影像学检查,筛选出健康个体396例(男160例,女236例,年龄30～99岁)。5年后随访,重复上述检查,有全部资料者224例(男85例,女139例,年龄36～93岁)。肾小球滤过率(GFR)由CKD-EPI公式估算。结果颈动脉斑块组血清CysC高于无颈动脉斑块组〔(0.898±0.155)vs(0.772±0.139)mg/L〕(P<0.01)。Spearman相关分析发现颈动脉斑块与血清CysC、年龄相关(r=0.398,P<0.01;r=0.462,P<0.01),Logistic回归分析显示CysC并非颈动脉斑块的独立危险因素。10岁年龄段分层,各层颈动脉斑块组与无颈动脉斑块组组间血清CysC无统计学差异(P>0.05)。根据5年前后斑块变化分为4组,1组:两次均无斑块组119例;2组:从有到无斑块组38例;3组:从无到有斑块组27例;4组:两次均有斑块组40例。单因素方差分析,2、3、4组5年前年龄、血清CysC浓度均较1组升高,3、4组5年前EPIGFR较1组低,5年前后血清CysC差值4组间无统学差异(P>0.05)。协方差分析调整年龄、性别、EPIGFR后,4组间无统计学差异(P>0.05)。结论血清CysC与颈动脉斑块无确切关联,不能作为其预测指标。Objective To investigate the correlation analysis between serum cystatin C and carotid plaque in asymptomatic adults.Methods The ones on the data base of 396 healthy subjects （males 160 and females 236,30～99 years old） were selected from 15 communities of Beijing,which in terms of questionnaire investigation,measurement of serum cystatin C,routine and biochemical indicator,physical examination,carotid artery ultrasound and imaging tests.5 years later,the follow-up was carried out.There were 224 subjects （males 85 and females 139,age varies from 36 to 93 years old） being followed up,and the above checks were repeatedly performed.Results Serum cystatin C levels were higher in with carotid plaque group than in without carotid plaque group〔（0.898±0.155） vs （0.772±0.139）mg/L,P0.01）〕.On Spearman correlation analysis,carotid plaque correlated positively to serum cystatin C and age （r=0.398,P0.01;r=0.462,P0.01）;the Logistic regression analysis show that cystatin C was not the independent risk factor for carotid plaque.In subgroups stratified by age,the difference of serum cystatin C between with and without carotid plaque groups was disappeared.According to the change of carotid plaque before and after 5 years,the subjects were divided in to 4 groups.There were 119 subjects in group A of two times without carotid plaque,38 subjects in group B of with to without carotid plaque,27 individuals in group C of without to with carotid plaque,40 subjects in group D of two times with carotid plaque.In analysis of the data in 5 years ago by one way analysis of variance,serum cystatin C levels in group B,C,D were respectively higher than those in group A,and levels of EPI GFR of group C,D were respectively lower than those in group A.In an analysis of covariance,after adjusted by age,gender and EPI GFR,the difference of serum cystatin C among 4 groups was disappeared（P0.05）.Conclusions There is no definite correlation between Serum cystatin C and carotid plaque,and serum cystatin C can not serve as

关 键 词：胱抑素C 颈动脉 增龄 肾小球滤过率 

分 类 号：R543.4[医药卫生—心血管疾病]