5'-核苷酸抗疲劳作用研究  

STUDY ON THE ANTI-FATIGUE EFFECT OF 5'-NUCLEOTIDE

作　　者：梁锐[1] 张召峰[1] 刘志刚[1] 张佳丽[1] 赵明[1] 王军波[1] 李勇[1] 

机构地区：[1]北京大学医学部公共卫生学院营养与食品卫生系,北京100191

出　　处：《现代预防医学》2010年第10期1853-1855,共3页Modern Preventive Medicine

摘　　要：[目的]研究5'-核苷酸抗疲劳作用。[方法]160只SPF级雄性ICR小鼠,随机分为4组,设立空白对照组、5'-核苷酸低、中、高剂量组(分别为0.04g/kg.bw、0.16g/kg.bw和0.64g/kg.bw)。30d后,测定各组小鼠负重游泳时间、血清尿素氮、肝糖原、血乳酸等指标。[结果]5'-核苷酸中、高剂量组均可显著延长小鼠负重游泳时间(P﹤0.05),并减少小鼠不负重游泳前及游泳后0min和20min3个时间点血乳酸测定曲线下的面积(P﹤0.05);5'-核苷酸各剂量组均可显著降低小鼠不负重游泳90min后血清尿素氮水平(P﹤0.05)。[结论]5'-核苷酸具有缓解体力疲劳功能。[Objective] To study the anti-fatigue effect of 5＇-nucleotide. [Methods] 160 mice were randomized divided into 4 groups： three groups of 5＇-nucleotide at dose of 0.04 g/kg.bw, 0.16 g/kg.bw, 0.64 g/kg.bw, and the blank control group. After 30 days feeding, mice were forced to swim, the loading swimming time, the content of liver glycogen, blood lactic acid and blood urea nitrogen were measured respectively. [Results] Group of 0.16 g/kg.bw and 0.64 g/kg.bw does could significantly increase the burden swimming time in mice, and decrease the determination of blood lactic acid of the area under the curve before and after un-weight swimming for 0min and 29min. Three 5＇-nucleotide groups could significantly lower the blood urea nitrogen 90 min after un-loading swimming. [Conclusion] 5＇-nucleotide has function of Alleviating Physical Fatigue.

关 键 词：5'-核苷酸 抗疲劳 血清尿素氮 肝糖原 血乳酸 

分 类 号：R285.5[医药卫生—中药学]