对比不同剂量腺苷对小型猪左冠状动脉血流及血流储备的影响  

Effects of adenosine on left coronary blood flow and flow reserve in mini-swine:a comparative study between different adenosine doses

作　　者：张庆勇[1] 王志华[1] 姚瑞明[2] 葛均波[2] 李京波[1] 魏盟[1] 

机构地区：[1]上海交通大学附属第六人民医院心内科,200233 [2]复旦大学附属中山医院心内科

出　　处：《介入放射学杂志》2010年第4期318-321,共4页Journal of Interventional Radiology

基　　金：上海市浦江人才计划(2008)

摘　　要：目的对比不同剂量的腺苷对巴马系小型猪左冠状动脉(冠脉)血流(CBF)及其储备(CFR)测量的影响。方法经导管于巴马系小型猪(n=10)左冠脉内团注不同剂量的腺苷(12、18、24和36μg),分别记录基础及充血状态下的心率、血压、基础CBF(rCBF)和最大充血时CBF(hCBF),以及CFR进行比较。结果冠脉内注射18μg腺苷可使血管最大扩张,18、24和36μg 3种不同剂量下测得的心率、血压、rCBF及CFR差异无统计学意义。而12μg腺苷剂量测得的hCBF分别同24和36μg测得的hCBF差异有统计学意义(P<0.05)。结论腺苷18～24μg剂量可使巴马系小型猪左冠脉最大扩张,并能获得CBF及CFR的有效测量。Objective To compare the effects of different doses of adenosine（AD） on the left coronary blood flow（CBF） and left coronary flow reserve（CFR） in mini-swine.Methods By using Doppler flow wire and intracoronary ultrasound imaging catheter at the middle segment of LAD,coronary average peak flow velocity（APV） and lumen area were measured in 10 healthy mini-swines.CBF was calculated from the equation of 0.6 APV times 0.5 lumen area.Intracoronary bolus injection of different dose AD（12 μg,18 μg,24 μg and 36 μg,separately） was used to induce maximal coronary hyperemic reaction.CFR was defined as the ratio of hyperemic CBF to resting CBF.Results Intracoronary bolus injection of 18μg AD level induced a maximal coronary vasodilation.Significant difference in the hyperemic CBF existed between 12 μg AD dose and 24 μg or 36 μg AD dose（P〈0.05）.No significant difference in heart rate,blood pressure,rCBF and CFR was found among three different AD dose groups（18 μg,24 μg,and 36 μg）.Conclusion CBF and CFR in mini-swine can be effectively assessed by bolus injection of AD with the dose of（18 ～ 24）μg.

关 键 词：冠状动脉微栓塞 微导管 动物模型 小型猪 

分 类 号：R543[医药卫生—心血管疾病]