基于动脉系统旋动流原理的一种血管内支架旋流导引装置的优化  

Optimization of a Helical Flow Inducer of Endovascular Stent Based on the Principle of Swirling Flow in Arterial System

作　　者：滕晓晶[1] 邓小燕[1] 

机构地区：[1]北京航空航天大学生物与医学工程学院,北京100191

出　　处：《生物医学工程学杂志》2010年第2期429-434,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(10632010)

摘　　要：血管内支架是目前治疗心血管疾病的主要方法之一。但是支架植入后的血管再狭窄问题至今未获完全解决。研究表明,支架植入后导致的局部血流紊乱和流场异常是造成再狭窄的主要原因之一。基于动脉系统的旋动流原理,设计了一种能够引导血流产生旋动的血管内支架旋流导引装置,并用计算流体力学的方法,对其进行了优化设计。流场数值研究表明,优化设计得到的旋流导引装置可产生足够强度的旋动流。我们相信,该装置产生的旋动流可有效抑制支架结构对血流的扰动,从而达到减缓血管再狭窄的目的。The implantation of endovascular stents is currently one of the main treatments for cardiovascular occlusion diseases.However,the problem of arterial restenosis after implantation has not been completely solved.It has been well documented that the disturbed local blood flow and abnormal flow environment due to the deployment of the stent is one of the major causes of restenosis.Based on the principle of swirling flow in the arterial system, in this research,a spiral flow guider for endovascular stent was proposed to induce the blood flow in the stent to rotate.Then a computational fluid dynamics（CFD） method was employed to optimize the design of the guider.The numerical simulation showed that the optimized guider could create sufficiently strong spiral flow that,we believe,can efficiently subdue the adverse disturbance to blood flow by the stent so that the arterial restenosis due to the stent implantation might be suppressed.

关 键 词：血管内支架 再狭窄 旋动流 计算流体力学 

分 类 号：R54[医药卫生—心血管疾病]