儿科用静脉营养液中加入蔗糖铁对脂肪乳剂稳定性的影响  

Effect of iron on the stability of fat emulsion in total nutrient admixture in pediatrics

作　　者：乔林霞[1] 汤庆娅[1] 费延文[1] 王莹[1] 

机构地区：[1]上海交通大学医学院附属新华医院临床营养中心,200092

出　　处：《中华临床营养杂志》2010年第2期111-114,共4页Chinese Journal of Clinical Nutrition

基　　金：基金项目：上海市医学重点学科项目（05111030）

摘　　要：目的评估静脉营养液（TNA）中加入蔗糖铁对脂肪乳剂稳定性的影响。方法根据静脉营养配制操作规范在100mlTNA中分别加入0、0．25、0．50、0．75、1．00mg铁剂，每组各10袋。在0、24、48、72h时，采用扫描电镜观察各组脂肪颗粒直径，计算出直径〉0．5μm颗粒的百分比；并测定各组TNA的pH值及渗透浓度。结果不同时间点各组TNA的脂肪颗粒直径、直径〉0．5μm的颗粒百分比、pH值及渗透浓度差异均无统计学性意义（P均〉0．05）。在72h内，各组脂肪颗粒平均直径均〈0．5μm，各组均未见到直径〉5μm的脂肪颗粒。结论含蔗糖铁浓度0．25—1．00mg／100ml的TNA是稳定的。Objective To evaluate the effect of iron on the stability of fat emulsion in total nutrient admixture （TNA） in pediatrics. Methods Based on intravenous nutrition preparation and handling protocols, 0, 0.25, 0. 50, 0. 75, and 1.00 mg iron sucrose was added in each 100 ml TNA, respectively, and each dose was prepared for 10 bags. The stability of fat emulsion was observed by electron scanning microscopy. The pH and osmolality were determined at different time points （0, 24, 48, and 72 h）. Results The fat particle size, percenta- ges of particles 〉 0. 5 μm, pH value, and osmolality were not significantly different among all the groups at different time points （ all P 〉 0.05 ）. The mean particle sizes of the fat emulsion were 〈 0. 5 μm in all groups within 72 h. No fat particle with diameter 〉 5μm was seen in each group. Conclusion TNA containing iron sucrose with concentrations range 0. 25-1. 00 mg per l 00 ml is stable.

关 键 词：静脉营养液 铁剂 脂肪乳剂 稳定性 

分 类 号：R45[医药卫生—治疗学]