氟乙酰胺中毒患者血液中氟乙酰胺和尿氟水平动态检测  

Development Change of Fluoroacetamide and Urine Fluoride of Acute Fluoroacetamide Poisoning

作　　者：翟增运[1] 

机构地区：[1]河南省安阳市疾病预防控制中心理化检验科,安阳市455000

出　　处：《医药论坛杂志》2010年第7期40-41,共2页Journal of Medical Forum

摘　　要：目的检测氟乙酰胺中毒患者血液中氟乙酰胺和尿氟水平的动态变化,并探讨二者的相关性。方法对65例急性氟乙酰胺中毒患者血液中氟乙酰胺、尿中无机氟进行连续动态监测,分析测定结果。结果急性氟乙酰胺中毒患者血液中氟乙酰胺含量显著增高,尿中无机氟测定值显著高于正常对照组。血液中氟乙酰胺第3h出现峰值,尿中无机氟第1d出现峰值,然后均随着中毒时间的延长而逐渐降低,无机氟第7d降至正常水平。结论氟乙酰胺中毒患者血液中氟乙酰胺含量与尿中无机氟高度相关(r=0.92)并呈现出规律性变化。Objective To moniter the dynamic changes of serum fluoroacetamide and urine fluoride in the acute toxicosis patients,and to explore their correlation.Methods The serum fluoroacetamide and urine fluoride of 65 cases of acute toxicosis patients were monitered continuously,analyse the determination results.Results The serum fluoroacetamide in patients with acute fluoroacetamide toxicosis is increased significantly,the level of urine fluoride was higher than that of the comparison group（P0.01）.Peak value of the serum fluoroacetamide appear on third hours,Peak value of the urine fluoride appear on first day,then decreased slowly with the exposure time,the level of urine fluoride dropped to the original level on the seventh day.Conclusion The serum fluoroacetamide and the urine fluoride of acute toxicosis patients altitude relevance（r=0.92）,And display regularity change.

关 键 词：中毒 氟乙酰胺 尿氟 动态检测 相关性 

分 类 号：R595.4[医药卫生—内科学]