骨髓间充质干细胞定向分化的经典WNT机制  

The canonical WNT signalling pathway mechanism of bone marrow-derived mesenchymal stem cells'directional differentiation

作　　者：许应星[1] 吴岩[1] 肖鲁伟 

机构地区：[1]浙江中医药大学第一临床医学院,杭州310053 [2]浙江省中医骨伤研究所,杭州310053

出　　处：《生命科学》2010年第4期372-376,共5页Chinese Bulletin of Life Sciences

基　　金：浙江省中医药科技计划重大项目(2006z003)

摘　　要：骨髓间充质干细胞的定向分化一直是干细胞研究的重点,在其分化过程中有多条信号通路参与和调节。目前,Wnt通路在骨髓间充质干细胞定向分化过程中的作用是国外的研究热点。研究发现经典Wnt通路的激活与骨髓间充质干细胞的定向分化高度相关,故将其近年来的研究综述如下,从而为骨质疏松等疾病的治疗以及骨组织工程的发展提供必要的参考依据。Bone marrow-derived mesenchymal stem cells＇ directional differentiation has been the emphasis of stem cell research,and some signalling pathways participate and regulate the differentiation. At present,the role of Wnt signalling pathway in the bone marrow-derived mesenchymal stem cells＇ directional differentiation is the focus of foreign research. The research indicates that the activation of canonical wnt signalling pathway is related to bone marrow-derived mesenchymal stem cells＇ directional differentiation. So we review the foreign research in recent years in order to offer necessary reference to the treatment of osteoporosis and the development of skeletal tissue engineering.

关 键 词：骨髓 间充质干细胞 WNT信号通路 分化 

分 类 号：Q813[生物学—生物工程] R681.2[医药卫生—骨科学]