阿片受体与吗啡镇痛耐受  

Opioid receptor and morphine tolerance to morphine analgesia

作　　者：陈默曦[1] 许涛[1] 江伟[1] 

机构地区：[1]上海交通大学附属第六人民医院麻醉科,200233

出　　处：《国际麻醉学与复苏杂志》2010年第2期174-177,共4页International Journal of Anesthesiology and Resuscitation

基　　金：高等学校博士学科点专项科研基金（200802480074）

摘　　要：长期使用阿片类物质如吗啡的主要限制在于生理耐受性的发生。耐受使吗啡的镇痛效果明显减弱。现从阿片受体下调、失敏感、G-蛋白下游信号转导等方面，将阿片受体参与吗啡镇痛耐受机制的研究进展作一综述。The major limitation to a long-term use of opioids, such as morphine, is the development of physiological tolerance, ob-served as a profound decrease in analgesic effect. Although the molecular and cellular mechanisms underlying the development of mor-phine tolerance remain controversial, great progress has been made. This review focuses on the opioid receptor with the aim of gaining a greater insight into the mechanism of morphine tolerance to analgesia.

关 键 词：阿片受体 吗啡 耐受 

分 类 号：R96[医药卫生—药理学]