联合抗氧化微量营养素对T1DM小鼠心肌超微结构的保护作用  

THE PROTECTION OF ANTIOXIDANT MICRONUTRIENTS ON MYOCARDIAL ULTRASTRUCTURE IN TYPE 1 DIABETIC MICE

作　　者：郑锦花[1] 朴松兰[2] 李洪霞[1] 张桂珍[1] 

机构地区：[1]吉林大学第三临床医学院中心研究室 [2]长春中医药大学病理教研室,长春130033

出　　处：《营养学报》2010年第2期138-140,共3页Acta Nutrimenta Sinica

基　　金：吉林省科技厅项目(No.20020704;No.2007-0722;No.2007-05265);国家自然科学基金(No.39870667)

摘　　要：目的探讨联合抗氧化微量营养素(combined antioxidant micronutrients,CAM)对心肌超微结构的保护作用。方法用小剂量多次注射链脲佐菌素法(multiple low dosage of streptozotocin,MLDS)制备T1DM(type1diabetes mellitus)小鼠模型,分别添加4和7种抗氧化微量营养素干预,观察心肌超微结构的变化。结果CAM使T1DM小鼠血糖明显降低;心肌微血管基底膜厚度明显小于T1DM模型组,线粒体肿胀明显减轻,肌丝结构有所改善。结论CAM对T1DM模型小鼠心肌超微结构具有保护作用。Objective To observe the effects of combined antioxidant micronutrients （CAM） on myocardium ultrastructure of type one diabetic mellitus （T1DM） mice. Method T1DM mice model was made by injection of multiple low dosages of streptozotocin （MLDS）. The supplementation of CAM was designed CAM4 and CAM7 two groups. The ultrastructure of myocardium in T1DM mice was observed by electron microscope and measured by computer image analysis method. Results The blood glucose level of mice in CAM4 and CAM7 groups was significantly decreased and the depth of microvascular basement membrane was smaller as compared with that of T1DM model group. The structure of mitochondria and myofilament was improved and the swelling of mitochondria was lightened in both CAM4 and CAM7 group. Conclusion Combined antioxidant micronutrients may protect ultrastructure of myocardium in T1DM mice.

关 键 词：I型糖尿病 抗氧化微量营养素 心肌 超微结构 

分 类 号：R587.2[医药卫生—内分泌]