连香方药自微乳载药系统的研究  

Study on Self-Microemulsifying Drug Delivery System of Lianxiang Prescription

作　　者：卢文彪[1] 陈蔚文[1] 李茹柳[1] 

机构地区：[1]广州中医药大学,广东广州510405

出　　处：《中药材》2010年第3期450-455,共6页Journal of Chinese Medicinal Materials

基　　金：广东省中医药局建设中医药强省科研课题(1060089)

摘　　要：目的:研制连香方药的自微乳载药系统。方法:经溶解度试验初步筛选后,采用三元相图法研究不同表面活性剂、助表面活性剂和油相体系自微乳化的能力和组成区域,筛选表面活性剂和助表面活性剂;在此基础上,考察方药组分、介质、温度等因素对体系自微乳化的能力和组成区域的影响,结合微乳粒径测定,筛选连香方药自微乳处方;进行稳定性及自微乳化速率的考察,初步评价自微乳处方。结果:优化的处方为黄连总生物碱-丁香油-Cremophor RH60-1,2-丙二醇(40∶20∶60∶20,w/w);处方经分散后可得到平均粒径为17.4 nm、PDI为0.176的微乳,稳定性好,自微乳化效率高。结论:优化的处方可作为连香方药的自微乳载药系统供后续研究。Objective： To prepare self-microemulsifying drug delivery system（SMEDDS） of LianXiang prescription. Methods： Af- ter the test of solubility for the initial screening, surfactants and cosurfactants with certain oil phase were screened through the study of ternary phase diagram and in accordance with the size of self-microemulsifying areas;To screen and optimize the self-microemulsifying formulation, the influence of related factors such as the ingredients of the prescription and dilution media on the self-microemulsifying areas were tested, and the particle dimension of microemulsion was determined. The tests of self-mieroemulsifying rate and stability were carried out to evaluate the formulation. Results： The total alkaloid of Coptis chinensis-the essential oil of Eugenia caryophyllata- Cremophor RH60-1,2-propylene glycol （ 40： 20： 60： 20, w/w ） was the optimal formulation ; it had good self-microemulsifying efficiency and stability, and its microemulsion had smaller particle dimension and polydispersity index（ 17.4 nm, 0. 176 ）. Conclusion ：The optimal formulation can be used as SMEDDS of LianXiang prescription for follow-up researches.

关 键 词：连香方 微乳 自微乳化载药系统 三元相图 

分 类 号：R283.6[医药卫生—中药学]