GCDFP-15在腋臭微创手术后残余大汗腺中的表达  

The Application of GCDFP-15 in Detecting the Residual Apocrine of Axillary Bromhidrosis in Microinvasive Surgery

作　　者：余光银[1] 李天石[1] 蔡广玲[1] 马雅[1] 陈耀丽[1] 

机构地区：[1]北京大学深圳医院病理科,广东深圳518036

出　　处：《贵阳医学院学报》2010年第2期168-170,共3页Journal of Guiyang Medical College

基　　金：深圳市科技计划基金资助项目(200803028)

摘　　要：目的:观察GCDFP-15在腋臭微创手术后大汗腺残余组织中的表达,判断手术是否彻底或吸刮过度的情况。方法:收集284例(双侧)腋臭微创手术刮出物标本,同时随机提取术后双侧腋窝0.2 cm×0.2 cm皮肤组织,用GCDFP-15进行免疫组织化学检测,判断微创术后大汗腺残留情况。结果:吸出物中均含有大量大汗腺并表达GCDFP-15,表达率100%,小汗腺不表达GCDFP-15;提取皮肤组织中有143例可见大汗腺导管,128例表达GCDFP-15(P>0.05),29例有可疑大汗腺残留,GCDFP-15标记3例为阳性(P<0.01)。结论:GCDFP-15在腋臭微创手术后残余大汗腺中有特异表达,可作为判断微创手术效果的病理依据。Objective：To find out whether the operation is complete or excessive curetting exists in microinvasive surgery by observing the expression of GCDFP-15 in the residual apocrine of axillary bromhidrosis.Methods： The apocrine sweat glaud（ASG） samples sucked out of axillary in 284（bilateral） bromhidrosis microinvasive cases were collected and 0.2 cm×0.2 cm skin tissues were randomly taken from both sides after operation.GCDFP-15 expression was detected with immunohistochemical staining method,and the postoperative residual ASG status was analyzed.Results： All of the extracted substance contained a large number of ASG.All of them expressed GCDFP-15,and the expression rate was 100%.Eccrine sweat glands did not express GCDFP-15;Extracted ASG duct could be seen in skin tissue of 143 cases by using HE staining method,and 128 cases of them expressed GCDFP-15（P0.05）;Uncertain residual ASG could be seen in skin tissue of 29 cases by HE staining,and 3 of them were proved GCDFP-15 positive expression（P0.01）.Conclusions： GCDFP-15 has specific expression in axillary bromhidrosis ASG residual of microinvasive surgery,and it could be used as pathological basis for evaluation of operation results.

关 键 词：臭汗症 外科手术 最小侵入性 大囊肿病液体蛋白-15 治疗结果 

分 类 号：R622.9[医药卫生—整形外科] R334.5[医药卫生—外科学]