革兰阴性菌对哌拉西林耐药性的国内文献分析  

Analysis of Piperacillin Resistance of Gram-negative Bacterial Strains Based on Domestic Literatures

作　　者：张兴艳[1,2] 王霆[1,2] 李长清 陈昭丽[1,2] 程泽能[1] 

机构地区：[1]中南大学药学院生物药剂教研室,长沙410013 [2]广州威尔曼药业有限公司 [3]湘北威尔曼制药有限公司及制药研究所

出　　处：《药物流行病学杂志》2010年第5期288-291,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:了解我国临床革兰阴性菌(G^-)对哌拉西林(PIP)的耐药动态。方法:利用中国知网检索相关文献,文献中的数据按不同地区、不同年份、不同种类菌株进行归类、计算和分析。结果:共筛选到文献104篇。经分析,2000～2007年,G^-菌和肠杆菌科细菌对PIP的耐药率逐年递增,非发酵G^-菌的耐药率不同年代间存在比较大的波动。肠杆菌的耐药率要高于非发酵G^-菌。不同地区、不同年份以及不同种类细菌对PIP的耐药性强弱、耐药性变化趋势上存在差异。结论:2000～2007年,我国临床G^-菌和肠杆菌科细菌对PIP的耐药率呈逐年上升趋势,而非发酵G^-菌的耐药性在不同地区、不同年份有集中爆发的趋势。Objective： To investigate piperacillin resistance of clinically isolated Gram-negative bacterial strains. Method： All references related to piperacillin resistance were retrieved through the internet CNKI. The resistance rates of different types of bacteria from various regions and years were re-calculated. Result： 104 documents were eventually chosen. The results showed that the resistant rates of Gram-negative bacterial strains and Enterobaeteriaeeae had been increasing year by year,while the resistance rates of Gram-negative bacterial strains fluctuated during different years from 2000 to 2007. However, the resistance rates of Enterobacteriaeeae to piperacillin were higher than those ofnon-fermentative Gramnegative bacterial strains. The resistance rates to piperacillin were different among types of bacteria, regions and years. Conclusion： The resistance rates of clinical Gram-negative bacteria and Enterobacteriaceae to piperacillin showed an upward tendency year by year in China from 2000 to 2007. However, the resistance of non-fermentative Gram-negative bacteria had an outbreak tendency in some regions and years.

关 键 词：哌拉西林 耐药率 革兰阴性菌 肠杆菌科细菌 非发酵革兰阴性菌 

分 类 号：R978.11[医药卫生—药品]