鱼腥草注射液新制剂抗炎解热作用及其机制研究  

Anti-inflammatory and antipyretic effect of new Houttuynia Cordata injection and the mechanism

作　　者：张美玉[1] 李贻奎[1] 闫位娟[1] 林成仁[1] 金龙[1] 张金艳[1] 何萍[1] 孙伟伟[1] 郝伟[1] 李连达[1] 

机构地区：[1]中国中医科学院西苑医院实验研究中心,北京100091

出　　处：《中国新药杂志》2010年第9期775-779,共5页Chinese Journal of New Drugs

基　　金：国家十一五科技支撑计划资助项目(2006BAI14B05)

摘　　要：目的:探讨鱼腥草注射液新制剂(NYI)抗炎、解热作用及其机制,并与原制剂(OYI)的作用进行比较。方法:采用二甲苯致小鼠耳廓肿和乙酸致小鼠腹腔毛细血管通透性实验模型来观察新制剂抗炎作用;采用酵母致大鼠发热、大肠杆菌内毒素(LPS)家兔发热模型,研究NYI的解热作用及其作用机制。结果:OYI和NYI的高、中剂量对二甲苯诱发小鼠耳肿胀和醋酸导致的小鼠腹腔毛细血管通透性亢进均有抑制作用,与模型对照组相比有显著性差异(P<0.05)。OYI和NYI的高、中剂量可降低干酵母导致大鼠体温升高(与模型对照组比较,P<0.05);OYI和NYI的高剂量可抑制LPS引起的家兔体温升高,并能够明显降低血清中TNF-α,IL-1β,IL-8,PGE2,与模型对照组相比有显著性差异(P<0.05)。结论:NYI具有明显的抗炎、解热作用,与OYI比较,无显著性差异。鱼腥草注射液可以抑制血清中TNF-α,IL-1β,IL-8和PGE2的含量,可能是其抗炎解热作用的机制之一。Objective：To study the anti-inflammatory and antipyretic effect of a new Houttuynia Cordata injection（NYI） and the mechanisms in comparison with the original Houttuynia Cordata injection（OYI）.Methods：To evaluate the anti-inflammatory effect,ear swelling was induced by dimethyl benzene,and the increased peritoneal capillary permeability was induced by acetic acid in mice.To evaluate the antipyretic effect,rectal temperature was monitored in rats with yeast liquid-induced fever and in rabbits with E.coli endotoxin（LPS）-induced fever.Results：The NYI and the OYI significantly inhibited the ear swelling and peritoneal effusion of Evans blue in mice（P〈0.05 vs control）.The OYI and high doses of NYI decreased the rectal temperature in rats（P〈0.05 vs control） and in rabbits.Both injections significantly reduced the contents of serum TNF-α,IL-1β,IL-8 and PGE2（P〈0.05）.Conclusion：NYI has an obvious anti-inflammatory and antipyretic effect as similar to the same dose of the OYI.NYI can inhibit serum TNF-α,IL-1β,IL-8 and PGE2,which may be one of the mechanisms.

关 键 词：鱼腥草注射液新制剂 抗炎 解热 肿瘤坏死因子-Α 白介素-1Β 白介素-8 前列腺素E2 

分 类 号：R285[医药卫生—中药学]