玉米须总黄酮对高脂血症大鼠血脂及血液流变学指标的影响  

Effects of flavones from Zea Mays L(ZMLF) on blood lipid and hemorheologic parameters in hyperlipemic rats

作　　者：景怡[1,2] 景荣琴 任远[2] 胡天惠[2] 

机构地区：[1]江苏淮阴工学院,淮安223003 [2]甘肃中医学院,兰州730000 [3]白银市第二人民医院药剂科,白银730900

出　　处：《中国新药杂志》2010年第9期797-800,共4页Chinese Journal of New Drugs

摘　　要：目的:研究玉米须总黄酮(totle flavone ofZea MaysL,ZMLF)对高脂血症模型大鼠血脂和血液流变学指标的影响。方法:Wistar大鼠60只随机分为5组,正常对照组喂普通饲料,其他各组喂饲高脂饲料建立高脂血症模型,各组按规定预防给药40 d后测定血清血脂水平及血液流变学指标。结果:ZMLF能明显降低高脂血症大鼠总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B100(apoB100)水平(P<0.05),升高高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AⅠ(apoAⅠ)含量和apoAⅠ/apoB100比值(P<0.05);全血低、中、高切粘度、血浆粘度、红细胞压积(HCT)、红细胞刚性指数(IER)、红细胞聚集指数(IEA)显著降低(P<0.05),红细胞变形指数(IED)升高(P<0.05)。结论:ZMLF能预防高脂饮食引起的脂代谢紊乱及血液流变学指标的异常变化。Objective：To explore the effects of flavones from Zea Mays L（ZMLF） on blood lipid and hemorheology in hyperlipidemic rats.Methods：Sixty Wistar rats were randomly divided into 5 groups;they fed with normal diet,or high fat diet to induce hyperlipidemia.ZMLF was administered for 40 days,then serum lipid and hemorrheologic indexes were measured.Results：The levels of TC,TG,LDL-C and apoB100 decreased significantly（P〈0.05）,and those of HDL-C,apoAI and apoAI/apoB100 ratio increased（P〈0.05）.The contents of the high,middle and low blood viscosity,plasma adhesion,hematocrit（HCT）,RBC rigid index（IER）,RBC aggregation index（IEA） decreased significantly（P〈0.05）;while RBC deformation index（IED） increased significantly（P〈0.05）.Conclusion：ZMLF can prevent high-fat diet-induced lipid metabolism disorders and the abnormal hemorheology.

关 键 词：玉米须总黄酮 高脂血症 血液流变学 血脂 

分 类 号：R285[医药卫生—中药学]