血清脂联素水平与高血压及心肌纤维化的关系  

The Relationship Between Adiponectin With Hypertension and Myocardial Fibrosis

作　　者：孟秋云[1] 李秀昌[2] 孙红[1] 李桂英[1] 

机构地区：[1]泰安市第四人民医院心内科,山东省271000 [2]泰山医学院附属医院

出　　处：《中国循环杂志》2010年第2期111-113,共3页Chinese Circulation Journal

摘　　要：目的:研究血清脂联素与高血压的关系,探讨高血压患者血清脂联素水平对心肌纤维化的影响,阐明高血压患者血清脂联素水平与心肌纤维化的关系。方法:根据美国预防、检测、评估与治疗高血压全国联合委员会第七次报告(JNC-7)的血压标准,筛选出33例高血压患者(高血压组),并筛选出同期在我院体检中心观察的健康人33例(正常对照组)。所有入选者清晨空腹抽取外周静脉血,用酶联免疫法测定血清脂联素、Ⅰ型前胶原羧基端肽(PⅠCP)和Ⅲ型前胶原氨基端肽(PⅢNP)水平。结果:与正常对照组相比,高血压组血清脂联素水平明显降低[(4.21±2.89)ng/ml比(2.69±1.00)ng/ml,P<0.01];且1级高血压患者与2级高血压患者血清脂联素比较明显升高,差异有统计学意义(P<0.05)。与正常对照组相比,高血压组PⅠCP和PⅢNP水平显著增高,PⅠCP分别为(13.10±6.56)ng/ml比(4.12±1.19)ng/ml,PⅢNP分别为(128.94±56.37)ng/ml比(66.70±11.72)ng/ml,两组比较差异均有统计学意义(P均<0.01)。相关分析表明,血清脂联素水平与PⅠCP及PⅢNP水平呈明显负相关(r分别为-0.245和-0.275,P均<0.05)。结论:高血压患者血清脂联素水平明显降低,血压越高脂联素水平越低,血清脂联素水平与PⅠCP及PⅢNP水平呈明显负相关,推测低水平的脂联素血症在高血压心肌纤维化中可能起重要作用。Objective： To investigate the relationship between serum adiponectin with hypertension and myocardial fibrosis. Methods ： There two groups of subjects were studied, Hypertension group, n = 33, patients were diagnosed according to the international standard, and Control group, n = 33, normal subjects were selected from physical examination of our hospital. The blood samples were phlebotomized and the levels of adiponectin, I precollagen carboxyl end peptide （ P I CP） and Ⅲ precollagen ammonia cardinal extremity peptide （P Ⅲ NP） were examined by enzyme-linked immunosorbnent assay （ELISA）. Results ： The serum adiponectin level was significantly lower in Hypertension group than that in Control group （2. 69 ± 1.0 ng/ml vs. 4. 21 ±2. 89 ng/ml,P 〈0.01 ）. The levels of P Ⅰ CP and PⅢNP were significantly higher in Hypertension group than that in Control group （13.10 ±6. 56 ng/ml vs. 4. 12 ± 1.19 ng/ml and 128.94 ±56. 37 ng/ml vs. 66. 70 Ⅲ 11.72 ng/ml respectively,P 〈 0.01 ）. The adiponectin level was negatively correlated with the levels of P Ⅰ CP and PⅢ NP （ r = - 0. 245 and - 0. 275 respectively,P 〈 0.05 ）. Conclusion：The adiponectin level was significantly lower in hypertensive patients than that in normal controls, P Ⅰ CP and P Ⅲ NP were negatively correlated with adiponectin. The low level of adiponeetin could play an important role in myocardial fibrosis in patients with hypertension.

关 键 词：高血压 脂联素 心肌纤维化 

分 类 号：R541[医药卫生—心血管疾病]